Acod1 aconitate decarboxylase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acod1provided by MGI
Official Full Name: aconitate decarboxylase 1provided by MGI
Primary source: MGI:MGI:103206
See related: Ensembl:ENSMUSG00000022126 AllianceGenome:MGI:103206
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAD; Irg1
Summary: Enables aconitate decarboxylase activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within response to lipopolysaccharide. Located in mitochondrion. Orthologous to human ACOD1 (aconitate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 2.1), CNS E14 (RPKM 0.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E2.3; 14 51.67 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (103284448..103294009)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (103047012..103056573)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis.
Title: The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis.
ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota.
Title: ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota.
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1.
Title: Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1.
Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis.
Title: Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis.
The Dual Role of ACOD1 in Inflammation.
Title: The Dual Role of ACOD1 in Inflammation.
Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression.
Title: Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression.
Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
Title: Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1.
Title: Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1.
IRG1 prevents excessive inflammatory responses and cardiac dysfunction after myocardial injury.
Title: IRG1 prevents excessive inflammatory responses and cardiac dysfunction after myocardial injury.
Deficiency of IRG1/ itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice.
Title: Deficiency of IRG1/ itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126378 (e-PCR)
- UniSTS:163086

PMC148819P6 (e-PCR)
- UniSTS:271019

L38281 (e-PCR)
- UniSTS:124906

AI323667 (e-PCR)
- UniSTS:180715

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aconitate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aconitate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aconitate decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aconitate decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to progesterone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of toll-like receptor 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of antimicrobial humoral response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in tolerance induction to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in tolerance induction to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cis-aconitate decarboxylase

Names: cis-aconitic acid decarboxylase; immune-responsive gene 1 protein; immunoresponsive gene 1

NP_032418.1

EC 4.1.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.