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    Irf2 interferon regulatory factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 16363, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Irf2provided by MGI
    Official Full Name
    interferon regulatory factor 2provided by MGI
    Primary source
    MGI:MGI:96591
    See related
    Ensembl:ENSMUSG00000031627 AllianceGenome:MGI:96591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irf-2; 9830146E22Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to virus; immune system process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; focal adhesion; and nucleoplasm. Predicted to be active in nucleus. Is expressed in eye; genitourinary system; heart; and limb. Orthologous to human IRF2 (interferon regulatory factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 5.7), colon adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Irf2 in Genome Data Viewer
    Location:
    8 B1.1; 8 26.42 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (47192751..47300493)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46739745..46847458)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6636 Neighboring gene predicted gene, 31111 Neighboring gene STARR-seq mESC enhancer starr_21392 Neighboring gene STARR-positive B cell enhancer mm9_chr8:47824808-47825109 Neighboring gene predicted gene, 16675 Neighboring gene VISTA enhancer mm9 Neighboring gene predicted gene, 31172 Neighboring gene STARR-seq mESC enhancer starr_21394 Neighboring gene STARR-positive B cell enhancer ABC_E6637 Neighboring gene STARR-positive B cell enhancer ABC_E10499 Neighboring gene predicted gene, 39170 Neighboring gene STARR-seq mESC enhancer starr_21395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:48005439-48005671 Neighboring gene STARR-positive B cell enhancer ABC_E2864 Neighboring gene STARR-positive B cell enhancer ABC_E5003 Neighboring gene STARR-positive B cell enhancer ABC_E6638 Neighboring gene predicted gene, 53417 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6 Neighboring gene STARR-seq mESC enhancer starr_21398 Neighboring gene predicted gene, 31231

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcription factor IRF2 drives interferon-mediated CD8(+) T cell exhaustion to restrict anti-tumor immunity. Lukhele S, et al. Immunity, 2022 Dec 13. PMID 36370712, Free PMC Article
    2. Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury. He T, et al. Drug Dev Res, 2022 Jun. PMID 35088417
    3. IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis. Li Y, et al. Mol Med Rep, 2022 Feb. PMID 34878155, Free PMC Article
    4. IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling. Kim I, et al. BMB Rep, 2021 Sep. PMID 34488926, Free PMC Article
    5. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages. Cui H, et al. J Immunol, 2018 May 1. PMID 29563175, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2.
      Title: Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2.
    2. Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury.
      Title: Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide-induced acute kidney injury.
    3. IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.
      Title: IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.
    4. IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-kappaB/NFATc1 signaling.
      Title: IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling.
    5. IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.
      Title: IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.
    6. Data show that interferon regulatory factor 2 (IRF2), a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the transcriptional activation of gasdermin-D (GSDMD).
      Title: IRF2 transcriptionally induces GSDMD expression for pyroptosis.
    7. The results point to a unique, cell-type selective role for IRF-2 in Innate lymphoid cells (ILC) development, acting at a discrete step critical for the generation of functionally competent Innate lymphoid cells precursors (ILCPs).
      Title: Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.
    8. The KRAS( *)-IRF2-CXCL3-CXCR2 axis drives colorectal cancer cell immune suppression and resistance to anti-PD-1 immunotherapy.
      Title: KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
    9. our data suggest that IRF2 is an important regulator of the proinflammatory response in macrophages by controlling HIF-1alpha-dependent glycolytic gene expression and glycolysis.
      Title: IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages.
    10. Data show that HCFC2 is a critical component of the IRF1 and IRF2 transcriptional machinery that regulates Tlr3 gene expression.
      Title: HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117893

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon regulatory factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008391.4 → NP_032417.3  interferon regulatory factor 2

      See identical proteins and their annotated locations for NP_032417.3

      Status: VALIDATED

      Source sequence(s)
      AK036652, AK132099
      Consensus CDS
      CCDS22295.1
      UniProtKB/Swiss-Prot
      P23906
      UniProtKB/TrEMBL
      Q2TAX8, Q3U2Z2, Q923E9
      Related
      ENSMUSP00000034041.8, ENSMUST00000034041.9
      Conserved Domains (1) summary
      pfam00605
      Location:7 → 112
      IRF; Interferon regulatory factor transcription factor

    RNA

    1. NR_152560.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116801, AC123751
      Related
      ENSMUST00000210284.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      47192751..47300493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509288.4 → XP_006509351.1  interferon regulatory factor 2 isoform X5

      See identical proteins and their annotated locations for XP_006509351.1

      UniProtKB/Swiss-Prot
      P23906
      UniProtKB/TrEMBL
      Q2TAX8, Q3U2Z2, Q923E9
      Conserved Domains (1) summary
      pfam00605
      Location:7 → 112
      IRF; Interferon regulatory factor transcription factor

    2. XM_011242175.4 → XP_011240477.1  interferon regulatory factor 2 isoform X1

      UniProtKB/TrEMBL
      Q2TAX8, Q923E9
      Conserved Domains (1) summary
      pfam00605
      Location:35 → 140
      IRF; Interferon regulatory factor transcription factor

    3. XM_006509289.5 → XP_006509352.1  interferon regulatory factor 2 isoform X5

      See identical proteins and their annotated locations for XP_006509352.1

      UniProtKB/Swiss-Prot
      P23906
      UniProtKB/TrEMBL
      Q2TAX8, Q3U2Z2, Q923E9
      Conserved Domains (1) summary
      pfam00605
      Location:7 → 112
      IRF; Interferon regulatory factor transcription factor

    4. XM_030243306.2 → XP_030099166.1  interferon regulatory factor 2 isoform X4

      UniProtKB/TrEMBL
      Q2TAX8, Q923E9
      Conserved Domains (1) summary
      pfam00605
      Location:12 → 117
      IRF; Interferon regulatory factor transcription factor

    5. XM_017312580.2 → XP_017168069.1  interferon regulatory factor 2 isoform X3

      UniProtKB/TrEMBL
      Q2TAX8, Q923E9
      Conserved Domains (1) summary
      pfam00605
      Location:28 → 133
      IRF; Interferon regulatory factor transcription factor

    6. XM_030243305.2 → XP_030099165.1  interferon regulatory factor 2 isoform X2

      UniProtKB/TrEMBL
      Q2TAX8, Q923E9
      Conserved Domains (1) summary
      pfam00605
      Location:35 → 140
      IRF; Interferon regulatory factor transcription factor

    RNA

    1. XR_001778407.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23906.1 GenPept UniProtKB/Swiss-Prot:P23906

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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