Inhbc inhibin beta-C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inhbcprovided by MGI
Official Full Name: inhibin beta-Cprovided by MGI
Primary source: MGI:MGI:105932
See related: Ensembl:ENSMUSG00000025405 AllianceGenome:MGI:105932
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]
Expression: Biased expression in liver adult (RPKM 24.9), liver E18 (RPKM 4.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127192191..127206417, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127356322..127370548, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results showed activin-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin-C. Study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.
Title: Regional localization of activin-β(A), activin-β(C), follistatin, proliferation, and apoptosis in adult and developing mouse prostate ducts.
Data reinforces the importance of activin-betaC in reproductive biology and suggests that activin-betaC is a tumor modulator with gonadal specificity.
Title: Activin-βC modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice.
results indicate that the beta(C) and beta(E) subunits of activin form homo- and heterodimers, and that the functions of the two subunits are quite different
Title: Comparison of the function of the beta(C) and beta(E) subunits of activin in AML12 hepatocytes.
Data support the conclusion that activin inhibits adrenal tumor growth promoted by luteinizing hormone by inducing adrenal x-zone regression.
Title: Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Inhbc (e-PCR), detects polymorphism
- UniSTS:496693

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inhibin beta C chain

Names: activin beta-C chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.