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    Incenp inner centromere protein [ Mus musculus (house mouse) ]

    Gene ID: 16319, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Incenpprovided by MGI
    Official Full Name
    inner centromere proteinprovided by MGI
    Primary source
    MGI:MGI:1313288
    See related
    Ensembl:ENSMUSG00000024660 AllianceGenome:MGI:1313288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130081E20; 2700067E22Rik
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including meiotic spindle midzone assembly; metaphase plate congression; and positive regulation of protein serine/threonine kinase activity. Predicted to act upstream of or within cell division. Located in several cellular components, including chromocenter; midbody; and synaptonemal complex. Is expressed in midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 26.8), CNS E11.5 (RPKM 25.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Incenp in Genome Data Viewer
    Location:
    19 A; 19 6.1 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (9849659..9876853, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (9872295..9899489, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45524 Neighboring gene syntaxin-binding protein 3, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45526 Neighboring gene STARR-seq mESC enhancer starr_45527 Neighboring gene STARR-seq mESC enhancer starr_45528 Neighboring gene STARR-seq mESC enhancer starr_45529 Neighboring gene STARR-seq mESC enhancer starr_45530 Neighboring gene STARR-seq mESC enhancer starr_45531 Neighboring gene secretoglobin, family 2A, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1972 Neighboring gene STARR-seq mESC enhancer starr_45534 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 50340 Neighboring gene STARR-positive B cell enhancer ABC_E5686 Neighboring gene predicted gene, 36913 Neighboring gene predicted gene, 41806

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP). Saffery R, et al. Mamm Genome, 1999 Apr. PMID 10087305
    2. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. Adams RR, et al. Chromosoma, 2001 May. PMID 11453556
    3. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Cutts SM, et al. Hum Mol Genet, 1999 Jul. PMID 10369859
    4. The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes. Sharif B, et al. J Cell Sci, 2010 Dec 15. PMID 21123620, Free PMC Article
    5. Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Tang CJ, et al. Dev Biol, 2006 Feb 15. PMID 16386730

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid separation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in central element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inner centromere protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369356.1 → NP_001356285.1  inner centromere protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132253
      Consensus CDS
      CCDS89338.1
      UniProtKB/Swiss-Prot
      Q7TN28, Q8BGN4, Q8CGI4, Q9WU62
      Related
      ENSMUSP00000157547.2, ENSMUST00000237439.2
      Conserved Domains (3) summary
      PTZ00121
      Location:513 → 656
      PTZ00121; MAEBL; Provisional
      pfam03941
      Location:795 → 849
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:6 → 41
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

    2. NM_016692.4 → NP_057901.2  inner centromere protein isoform 2

      See identical proteins and their annotated locations for NP_057901.2

      Status: VALIDATED

      Source sequence(s)
      AC132253
      Consensus CDS
      CCDS37912.1
      UniProtKB/Swiss-Prot
      Q9WU62
      Related
      ENSMUSP00000025562.8, ENSMUST00000025562.9
      Conserved Domains (4) summary
      pfam03941
      Location:795 → 846
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:6 → 41
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cd16269
      Location:588 → 599
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:515 → 619
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      9849659..9876853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526708.2 → XP_006526771.2  inner centromere protein isoform X2

      Conserved Domains (4) summary
      PTZ00121
      Location:503 → 659
      PTZ00121; MAEBL; Provisional
      pfam03941
      Location:798 → 852
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam09726
      Location:394 → 595
      Macoilin; Macoilin family
      pfam12178
      Location:13 → 48
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

    2. XM_006526710.2 → XP_006526773.2  inner centromere protein isoform X4

      Conserved Domains (4) summary
      PTZ00121
      Location:520 → 625
      PTZ00121; MAEBL; Provisional
      pfam03941
      Location:762 → 816
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam09726
      Location:394 → 582
      Macoilin; Macoilin family
      pfam12178
      Location:13 → 48
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

    3. XM_011247154.1 → XP_011245456.1  inner centromere protein isoform X3

      Conserved Domains (4) summary
      PTZ00121
      Location:516 → 663
      PTZ00121; MAEBL; Provisional
      pfam03941
      Location:782 → 836
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam09726
      Location:394 → 599
      Macoilin; Macoilin family
      pfam12178
      Location:13 → 48
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

    4. XM_006526707.2 → XP_006526770.2  inner centromere protein isoform X1

      Conserved Domains (4) summary
      PTZ00121
      Location:520 → 663
      PTZ00121; MAEBL; Provisional
      pfam03941
      Location:802 → 856
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam09726
      Location:394 → 599
      Macoilin; Macoilin family
      pfam12178
      Location:13 → 48
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WU62.2 GenPept UniProtKB/Swiss-Prot:Q9WU62

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