Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrig1provided by MGI
Official Full Name: leucine-rich repeats and immunoglobulin-like domains 1provided by MGI
Primary source: MGI:MGI:107935
See related: Ensembl:ENSMUSG00000030029 AllianceGenome:MGI:107935
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Img; LIG-1; D6Bwg0781e
Summary: Acts upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 30.2), cerebellum adult (RPKM 20.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D2; 6 43.15 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (94581510..94677205, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (94604529..94700298, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrig1 drives cryptogenesis and restrains proliferation during colon development.
Title: Lrig1 drives cryptogenesis and restrains proliferation during colon development.
Lrig1-expression confers suppressive function to CD4[+] cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis.
Title: Lrig1-expression confers suppressive function to CD4(+) cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis.
Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation.
Title: Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation.
Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis.
Title: Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis.
Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice.
Title: Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice.
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
Title: Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
Title: LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.
Title: Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells.
Title: LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells.
remarkable impact on epidermal development and homeostasis, disrupting ERBB-signaling and affecting epidermal stem cells
Title: Epidermal overexpression of LRIG1 disturbs development and homeostasis in skin by disrupting the ERBB system.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (10) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW557176 (e-PCR)
- UniSTS:185674

RH125079 (e-PCR)
- UniSTS:161901

Lrig1 (e-PCR), detects polymorphism
- UniSTS:507035

D5Bwg0834e (e-PCR), detects polymorphism
- UniSTS:142537

Lrig1 (e-PCR), detects polymorphism
- UniSTS:525550

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within hair cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innervation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otolith morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeats and immunoglobulin-like domains protein 1

Names: integral membrane glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355269.2 → NP_001342198.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC122272, AC155330

UniProtKB/TrEMBL

B7ZP45

Conserved Domains (7) summary

cd05763
Location:618 → 692

Ig_1; Subgroup of the immunoglobulin (Ig) superfamily

smart00082
Location:444 → 492

LRRCT; Leucine rich repeat C-terminal domain

COG4886
Location:78 → 330

LRR; Leucine-rich repeat (LRR) protein [Transcription]

pfam07679
Location:695 → 782

I-set; Immunoglobulin I-set domain

sd00033
Location:143 → 166

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:385 → 441

LRR_8; Leucine rich repeat

pfam13927
Location:496 → 583

Ig_3; Immunoglobulin domain
NM_001410069.1 → NP_001396998.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC122272, AC155330
NM_001410070.1 → NP_001396999.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC122272, AC155330
NM_008377.3 → NP_032403.2 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_032403.2

Status: VALIDATED

Source sequence(s)

AC122272, AC155330

Consensus CDS

CCDS20380.1

UniProtKB/Swiss-Prot

E9QL89, P70193

UniProtKB/TrEMBL

B7ZP45

Related

ENSMUSP00000098686.3, ENSMUST00000101126.3

Conserved Domains (8) summary

cd05763
Location:618 → 692

Ig_1; Subgroup of the immunoglobulin (Ig) superfamily

smart00408
Location:709 → 772

IGc2; Immunoglobulin C-2 Type

smart00082
Location:444 → 492

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:57 → 325

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam07679
Location:601 → 691

I-set; Immunoglobulin I-set domain

sd00033
Location:143 → 166

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:213 → 273

LRR_8; Leucine rich repeat

pfam13927
Location:496 → 583

Ig_3; Immunoglobulin domain

RNA

NR_176936.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122272, AC155330
NR_176937.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122272, AC155330

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

94581510..94677205 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255196.2 → XP_030111056.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

Conserved Domains (6) summary

cd05763
Location:356 → 430

Ig_1; Subgroup of the immunoglobulin (Ig) superfamily

smart00082
Location:182 → 230

LRRCT; Leucine rich repeat C-terminal domain

sd00033
Location:3 → 24

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:123 → 179

LRR_8; Leucine rich repeat

pfam07679
Location:433 → 520

I-set; Immunoglobulin I-set domain

cl11960
Location:235 → 335

Ig; Immunoglobulin domain
XM_030255198.1 → XP_030111058.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

Conserved Domains (6) summary

cd05763
Location:356 → 430

Ig_1; Subgroup of the immunoglobulin (Ig) superfamily

smart00082
Location:182 → 230

LRRCT; Leucine rich repeat C-terminal domain

sd00033
Location:3 → 24

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:123 → 179

LRR_8; Leucine rich repeat

pfam07679
Location:433 → 520

I-set; Immunoglobulin I-set domain

cl11960
Location:235 → 335

Ig; Immunoglobulin domain
XM_036165882.1 → XP_036021775.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

UniProtKB/TrEMBL

B7ZP45

Conserved Domains (7) summary

smart00082
Location:339 → 387

LRRCT; Leucine rich repeat C-terminal domain

sd00033
Location:38 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam07679
Location:590 → 677

I-set; Immunoglobulin I-set domain

pfam13927
Location:391 → 478

Ig_3; Immunoglobulin domain

cd00096
Location:598 → 601

Ig; Ig strand A' [structural motif]

cd05763
Location:497 → 587

IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains

cd21340
Location:20 → 220

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_030255197.1 → XP_030111057.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

Conserved Domains (6) summary

cd05763
Location:356 → 430

Ig_1; Subgroup of the immunoglobulin (Ig) superfamily

smart00082
Location:182 → 230

LRRCT; Leucine rich repeat C-terminal domain

sd00033
Location:3 → 24

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:123 → 179

LRR_8; Leucine rich repeat

pfam07679
Location:433 → 520

I-set; Immunoglobulin I-set domain

cl11960
Location:235 → 335

Ig; Immunoglobulin domain