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    Il1rn interleukin 1 receptor antagonist [ Mus musculus (house mouse) ]

    Gene ID: 16181, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Il1rnprovided by MGI
    Official Full Name
    interleukin 1 receptor antagonistprovided by MGI
    Primary source
    MGI:MGI:96547
    See related
    Ensembl:ENSMUSG00000026981 AllianceGenome:MGI:96547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-1ra; F630041P17Rik
    Summary
    Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E18 (RPKM 5.5), colon adult (RPKM 5.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A3; 2 16.36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24226872..24241503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24336860..24351491)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 36 receptor antagonist Neighboring gene STARR-positive B cell enhancer ABC_E7798 Neighboring gene interleukin 1 family, member 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24238515-24238668 Neighboring gene STARR-positive B cell enhancer ABC_E11125 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene paired box 8 Neighboring gene predicted gene 13415

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increase in the Number of Bone Marrow Osteoclast Precursors at Different Skeletal Sites, Particularly in Long Bone and Jaw Marrow in Mice Lacking IL-1RA. Ascone G, et al. Int J Mol Sci, 2020 May 27. PMID 32471111, Free PMC Article
    2. Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice. Rogier R, et al. PLoS One, 2019. PMID 31283798, Free PMC Article
    3. Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist. Lee K, et al. PLoS One, 2018. PMID 29481574, Free PMC Article
    4. Airway Remodeling and Hyperreactivity in a Model of Bronchopulmonary Dysplasia and Their Modulation by IL-1 Receptor Antagonist. Royce SG, et al. Am J Respir Cell Mol Biol, 2016 Dec. PMID 27482635
    5. Apoptotic Cells Release IL1 Receptor Antagonist in Response to Genotoxic Stress. Chwee JY, et al. Cancer Immunol Res, 2016 Apr. PMID 26873573

    See all (196) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.
      Title: Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.
    2. The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
      Title: The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
    3. Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.
      Title: Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.
    4. Hypoxia inducible factor 1alpha promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury.
      Title: Hypoxia inducible factor 1α promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury.
    5. Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.
      Title: Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.
    6. Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.
      Title: Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.
    7. IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
      Title: IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
    8. Impact of thermogenesis induced by chronic beta3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
      Title: Impact of thermogenesis induced by chronic β3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
    9. Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke.
      Title: Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke.
    10. Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3.
      Title: Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-1 receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1 type I receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1 type II receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1, type I receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1, type II receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acute-phase response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fever generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response to antigenic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-1 receptor antagonist protein
    Names
    IL-1RN
    IL1 inhibitor
    IRAP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039701.3 → NP_001034790.1  interleukin-1 receptor antagonist protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001034790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment compared to variant 3, that removes the translation initiation site. The resulting isoform (2) starts at a downstream AUG and has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AK155641, AL732528
      Consensus CDS
      CCDS38064.1
      UniProtKB/Swiss-Prot
      O70207, P25085
      UniProtKB/TrEMBL
      Q542C7, Q8CGA1
      Related
      ENSMUSP00000110126.2, ENSMUST00000114482.3
      Conserved Domains (1) summary
      smart00125
      Location:34 → 175
      IL1; Interleukin-1 homologues

    2. NM_001159562.1 → NP_001153034.1  interleukin-1 receptor antagonist protein isoform 3

      See identical proteins and their annotated locations for NP_001153034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AL732528, BY206809
      Consensus CDS
      CCDS50520.1
      UniProtKB/TrEMBL
      Q3TBV5, Q8CGA1
      Related
      ENSMUSP00000110129.3, ENSMUST00000114485.9
      Conserved Domains (1) summary
      smart00125
      Location:18 → 159
      IL1; Interleukin-1 homologues

    3. NM_031167.5 → NP_112444.1  interleukin-1 receptor antagonist protein isoform 1

      See identical proteins and their annotated locations for NP_112444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AK076296, AL732528
      Consensus CDS
      CCDS15736.1
      UniProtKB/TrEMBL
      Q542W1, Q8CGA1
      Related
      ENSMUSP00000110131.3, ENSMUST00000114487.9
      Conserved Domains (1) summary
      smart00125
      Location:15 → 156
      IL1; Interleukin-1 homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24226872..24241503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497727.4 → XP_006497790.1  interleukin-1 receptor antagonist protein isoform X1

      UniProtKB/TrEMBL
      Q8CGA1
      Conserved Domains (1) summary
      smart00125
      Location:1 → 140
      IL1; Interleukin-1 homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25085.1 GenPept UniProtKB/Swiss-Prot:P25085

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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