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    Il1r1 interleukin 1 receptor, type I [ Mus musculus (house mouse) ]

    Gene ID: 16177, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Il1r1provided by MGI
    Official Full Name
    interleukin 1 receptor, type Iprovided by MGI
    Primary source
    MGI:MGI:96545
    See related
    Ensembl:ENSMUSG00000026072 AllianceGenome:MGI:96545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-iR; CD121a; CD121b; IL-1R1; Il1r-1; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha
    Summary
    Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in brain; dorsal aorta; liver; reproductive system; and spleen. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E18 (RPKM 5.6), bladder adult (RPKM 4.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 B; 1 18.81 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40261651..40355361)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40222480..40316201)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:40142581-40142881 Neighboring gene predicted gene, 16894 Neighboring gene STARR-seq mESC enhancer starr_00736 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741 Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene STARR-seq mESC enhancer starr_00738 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_00741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis. Luo M, et al. Biochem Biophys Res Commun, 2022 Sep 10. PMID 35777130
    2. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Li X, et al. Cell, 2022 May 12. PMID 35483374, Free PMC Article
    3. The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice. Narayan P, et al. Cytokine, 2022 Mar. PMID 35091314
    4. Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice. McMurray KMJ, et al. Brain Behav Immun, 2022 Mar. PMID 35032573, Free PMC Article
    5. The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection. Ralph BA, et al. Front Immunol, 2021. PMID 34322116, Free PMC Article

    See all (762) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation.
      Title: M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation.
    2. IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury.
      Title: IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury.
    3. Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1-IL1R1 Interaction in Mice.
      Title: Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1-IL1R1 Interaction in Mice.
    4. IL-1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis.
      Title: IL-1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis.
    5. Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.
      Title: Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.
    6. The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
      Title: The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
    7. IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
      Title: IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
    8. IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
      Title: IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
    9. Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.
      Title: Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.
    10. Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling.
      Title: Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (150)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129154

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-1 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-1 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables interleukin-1 receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables interleukin-1 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1, type I, activating receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heat acclimation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-1-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T-helper 1 cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-1-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neutrophil extravasation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor type 1
    Names
    CD121 antigen-like family member A
    IL-1 receptor alpha chain
    interleukin-1 receptor alpha
    NP_001116854.1
    NP_032388.1
    XP_006495776.1
    XP_006495777.1
    XP_006495785.1
    XP_006495786.1
    XP_030106479.1
    XP_036018058.1
    XP_036018071.1
    XP_036018078.1
    XP_036018079.1
    XP_036018081.1
    XP_036018088.1
    XP_036018090.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123382.2 → NP_001116854.1  interleukin-1 receptor type 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001116854.1

      Status: VALIDATED

      Source sequence(s)
      AC135085, AC167168
      Consensus CDS
      CCDS48246.1
      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Related
      ENSMUSP00000110443.2, ENSMUST00000114795.3
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    2. NM_008362.3 → NP_032388.1  interleukin-1 receptor type 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032388.1

      Status: VALIDATED

      Source sequence(s)
      AC135085, AC167168
      Consensus CDS
      CCDS35547.1
      UniProtKB/Swiss-Prot
      P13504
      UniProtKB/TrEMBL
      Q32MH0, Q8C6P3
      Related
      ENSMUSP00000027241.5, ENSMUST00000027241.11
      Conserved Domains (4) summary
      smart00255
      Location:387 → 542
      TIR; Toll - interleukin 1 - resistance
      cd05757
      Location:131 → 220
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      pfam13927
      Location:229 → 319
      Ig_3; Immunoglobulin domain
      cl11960
      Location:31 → 116
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      40261651..40355361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495713.4 → XP_006495776.1  interleukin-1 receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_006495776.1

      UniProtKB/Swiss-Prot
      P13504
      UniProtKB/TrEMBL
      Q32MH0, Q8C6P3
      Conserved Domains (4) summary
      smart00255
      Location:387 → 542
      TIR; Toll - interleukin 1 - resistance
      cd05757
      Location:131 → 220
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      pfam13927
      Location:229 → 319
      Ig_3; Immunoglobulin domain
      cl11960
      Location:31 → 116
      Ig; Immunoglobulin domain

    2. XM_006495722.4 → XP_006495785.1  interleukin-1 receptor type 1 isoform X2

      See identical proteins and their annotated locations for XP_006495785.1

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    3. XM_030250619.2 → XP_030106479.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    4. XM_036162185.1 → XP_036018078.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    5. XM_036162197.1 → XP_036018090.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    6. XM_036162186.1 → XP_036018079.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    7. XM_006495723.5 → XP_006495786.1  interleukin-1 receptor type 1 isoform X2

      See identical proteins and their annotated locations for XP_006495786.1

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    8. XM_036162195.1 → XP_036018088.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    9. XM_036162178.1 → XP_036018071.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    10. XM_036162165.1 → XP_036018058.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    11. XM_006495714.5 → XP_006495777.1  interleukin-1 receptor type 1 isoform X2

      See identical proteins and their annotated locations for XP_006495777.1

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain

    12. XM_036162188.1 → XP_036018081.1  interleukin-1 receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Conserved Domains (3) summary
      smart00255
      Location:384 → 539
      TIR; Toll - interleukin 1 - resistance
      cd00096
      Location:226 → 229
      Ig; Ig strand A [structural motif]
      cl11960
      Location:226 → 329
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13504.1 GenPept UniProtKB/Swiss-Prot:P13504

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