Il15ra interleukin 15 receptor, alpha chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il15raprovided by MGI
Official Full Name: interleukin 15 receptor, alpha chainprovided by MGI
Primary source: MGI:MGI:104644
See related: Ensembl:ENSMUSG00000023206 AllianceGenome:MGI:104644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-15RA
Summary: Predicted to enable interleukin-15 receptor activity and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell differentiation. Located in cytoplasmic vesicle and plasma membrane. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human IL15RA (interleukin 15 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 8.1), liver E18 (RPKM 7.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 8.97 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (11709992..11739129)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (11705172..11733985)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabolic responses in the cortex and hippocampus induced by Il-15ralpha mutation.
Title: Metabolic responses in the cortex and hippocampus induced by Il-15rα mutation.
IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A New Pathway in Chronic Kidney Disease?
Title: IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A New Pathway in Chronic Kidney Disease?
Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor alpha Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
Title: Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
IL-15/IL-15Ralpha Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models.
Title: IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models.
Our proof-of-concept preclinical studies demonstrate the safety and efficacy of the adipocyte-specific IL-15/IL-15Ralpha complex vector as a novel cancer immune gene therapy.
Title: Adipocytes: A Novel Target for IL-15/IL-15Rα Cancer Gene Therapy.
The higher cristae density in Il15ra (-/-) mitochondria was associated with higher OPA1 and cardiolipin levels. Overall, these data extend our understanding of the role of IL15RA signaling in muscle oxidative metabolism and adaptation to exercise.
Title: Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA.
IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation.
Title: Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα.
data reveal a critical function of Shp-2 as a molecular nexus bridging acute IL-15 signaling with downstream metabolic burst and NK cell expansion.
Title: Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
these data support that IL15RA plays a cell-autonomous role in osteoblast function and bone mineralization
Title: IL15RA is required for osteoblast function and bone mineralization.
IL-15, but not IL-15Ralpha, is required for the development of spontaneous and virus-induced Type 1 diabetes.
Title: Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

U22339 (e-PCR)
- UniSTS:125698

AA690181 (e-PCR)
- UniSTS:165145

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-15 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-15 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-15 receptor subunit alpha

Names: IL-15 receptor subunit alpha; IL-15R-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271497.2 → NP_001258426.1 interleukin-15 receptor subunit alpha isoform 2

See identical proteins and their annotated locations for NP_001258426.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5'-most exon and uses an alternate donor splice site in another exon in the 5' UTR compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 14, and 15 all encode the same isoform (2).

Source sequence(s)

AL831794

Consensus CDS

CCDS15687.1

UniProtKB/TrEMBL

Q501M1

Related

ENSMUSP00000131473.2, ENSMUST00000138349.8
NM_001271498.2 → NP_001258427.1 interleukin-15 receptor subunit alpha isoform 3

See identical proteins and their annotated locations for NP_001258427.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in both UTRs and has multiple coding differences, one of which causes a frameshift, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus and distinct C-terminus compared to isoform 1. Variants 4 and 17 both encode the same isoform (3).

Source sequence(s)

AL831794

Consensus CDS

CCDS70980.1

UniProtKB/TrEMBL

Q810T6

Related

ENSMUSP00000132058.2, ENSMUST00000148748.8
NM_001271499.2 → NP_001258428.1 interleukin-15 receptor subunit alpha isoform 4 precursor

See identical proteins and their annotated locations for NP_001258428.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 4 (also known as isoform 1A) which is shorter than isoform 1.

Source sequence(s)

AL831794

Consensus CDS

CCDS70977.1

UniProtKB/Swiss-Prot

Q60819

Related

ENSMUSP00000110480.3, ENSMUST00000114831.9

Conserved Domains (1) summary

cd00033
Location:36 → 97

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_001271500.2 → NP_001258429.1 interleukin-15 receptor subunit alpha isoform 5 precursor

See identical proteins and their annotated locations for NP_001258429.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 5 (also known as isoform 1B) which is shorter than isoform 1.

Source sequence(s)

AL831794

Consensus CDS

CCDS70978.1

UniProtKB/Swiss-Prot

Q60819

Related

ENSMUSP00000110483.4, ENSMUST00000114834.10

Conserved Domains (1) summary

smart00032
Location:36 → 96

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
NM_001271501.2 → NP_001258430.1 interleukin-15 receptor subunit alpha isoform 6 precursor

See identical proteins and their annotated locations for NP_001258430.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 6 (also known as isoform 1C) which is shorter than isoform 1.

Source sequence(s)

AL831794

Consensus CDS

CCDS70979.1

UniProtKB/Swiss-Prot

Q60819

Related

ENSMUSP00000110482.4, ENSMUST00000114833.10

Conserved Domains (1) summary

cd00033
Location:36 → 97

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_001420303.1 → NP_001407232.1 interleukin-15 receptor subunit alpha isoform 7

Status: VALIDATED

Source sequence(s)

AL831794

UniProtKB/TrEMBL

Q80SW0
NM_001420304.1 → NP_001407233.1 interleukin-15 receptor subunit alpha isoform 7

Status: VALIDATED

Source sequence(s)

AL831794

UniProtKB/TrEMBL

Q80SW0
NM_001420305.1 → NP_001407234.1 interleukin-15 receptor subunit alpha isoform 8 precursor

Status: VALIDATED

Source sequence(s)

AL831794
NM_001420306.1 → NP_001407235.1 interleukin-15 receptor subunit alpha isoform 9 precursor

Status: VALIDATED

Source sequence(s)

AL831794
NM_001420307.1 → NP_001407236.1 interleukin-15 receptor subunit alpha isoform 10 precursor

Status: VALIDATED

Source sequence(s)

AL831794
NM_001420308.1 → NP_001407237.1 interleukin-15 receptor subunit alpha isoform 11 precursor

Status: VALIDATED

Source sequence(s)

AL831794
NM_001420310.1 → NP_001407239.1 interleukin-15 receptor subunit alpha isoform 2

Status: VALIDATED

Source sequence(s)

AL831794

UniProtKB/TrEMBL

Q501M1
NM_001420311.1 → NP_001407240.1 interleukin-15 receptor subunit alpha isoform 2

Status: VALIDATED

Source sequence(s)

AL831794

UniProtKB/TrEMBL

Q501M1
NM_001420315.1 → NP_001407244.1 interleukin-15 receptor subunit alpha isoform 12

Status: VALIDATED

Source sequence(s)

AL831794
NM_001420317.1 → NP_001407246.1 interleukin-15 receptor subunit alpha isoform 3

Status: VALIDATED

Source sequence(s)

AL831794

UniProtKB/TrEMBL

Q810T6
NM_001420318.1 → NP_001407247.1 interleukin-15 receptor subunit alpha isoform 7

Status: VALIDATED

Source sequence(s)

AL831794

UniProtKB/TrEMBL

Q80SW0
NM_001420319.1 → NP_001407248.1 interleukin-15 receptor subunit alpha isoform 13

Status: VALIDATED

Source sequence(s)

AL831794
NM_001420321.1 → NP_001407250.1 interleukin-15 receptor subunit alpha isoform 13

Status: VALIDATED

Source sequence(s)

AL831794
NM_008358.3 → NP_032384.1 interleukin-15 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_032384.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL831794

Consensus CDS

CCDS15686.1

UniProtKB/Swiss-Prot

A2AP35, A2AP36, A2AP37, Q60819, Q80Z90, Q80Z91, Q80Z92, Q8R5E4

Related

ENSMUSP00000077878.6, ENSMUST00000078834.12

Conserved Domains (1) summary

cd00033
Location:36 → 97

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_133836.3 → NP_598597.1 interleukin-15 receptor subunit alpha isoform 2

See identical proteins and their annotated locations for NP_598597.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5'-most exon in the 5' UTR compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 14, and 15 all encode the same isoform (2).

Source sequence(s)

AL831794

Consensus CDS

CCDS15687.1

UniProtKB/TrEMBL

Q501M1

Related

ENSMUSP00000126364.2, ENSMUST00000128156.9

RNA

NR_185161.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL831794
NR_185162.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL831794

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

11709992..11739129

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247643.2 → XP_030103503.1 interleukin-15 receptor subunit alpha isoform X6
XM_030247644.2 → XP_030103504.1 interleukin-15 receptor subunit alpha isoform X7

UniProtKB/TrEMBL

Q501M1
XM_017315695.3 → XP_017171184.1 interleukin-15 receptor subunit alpha isoform X5

UniProtKB/Swiss-Prot

Q60819

Related

ENSMUSP00000110481.3, ENSMUST00000114832.3

Conserved Domains (1) summary

cd00033
Location:36 → 97

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_006497359.4 → XP_006497422.1 interleukin-15 receptor subunit alpha isoform X2

Conserved Domains (1) summary

cd00033
Location:36 → 97

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
XM_006497360.4 → XP_006497423.1 interleukin-15 receptor subunit alpha isoform X3

RNA

XR_003950824.2 RNA Sequence
XR_865926.4 RNA Sequence
XR_004938395.1 RNA Sequence
XR_865924.4 RNA Sequence
XR_865925.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_073191.1: Suppressed sequence

Description

NR_073191.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
NR_073192.1: Suppressed sequence

Description

NR_073192.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.