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    Il13ra2 interleukin 13 receptor, alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 16165, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Il13ra2provided by MGI
    Official Full Name
    interleukin 13 receptor, alpha 2provided by MGI
    Primary source
    MGI:MGI:1277954
    See related
    Ensembl:ENSMUSG00000031289 AllianceGenome:MGI:1277954
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD213a2; IL-13R-alpha-2
    Summary
    This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in bladder adult (RPKM 1.3), frontal lobe adult (RPKM 0.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F2; X 68.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (146166474..146214982, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (147383478..147429192, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2C Neighboring gene microRNA 1911 Neighboring gene microRNA 448 Neighboring gene STARR-seq mESC enhancer starr_48057 Neighboring gene vomeronasal 1 receptor 239, pseudogene Neighboring gene predicted gene, 25107 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis. Xiao S, et al. Brain Behav Immun, 2021 Nov. PMID 34391816
    2. Detecting Chronic Post-Traumatic Osteomyelitis of Mouse Tibia via an IL-13Rα2 Targeted Metallofullerene Magnetic Resonance Imaging Probe. Xiao L, et al. Bioconjug Chem, 2017 Feb 15. PMID 28061526, Free PMC Article
    3. Modulation of pulmonary fibrosis by IL-13Rα2. Lumsden RV, et al. Am J Physiol Lung Cell Mol Physiol, 2015 Apr 1. PMID 25659898
    4. IL-13 receptor α2 contributes to development of experimental allergic asthma. Chen W, et al. J Allergy Clin Immunol, 2013 Oct. PMID 23763980, Free PMC Article
    5. Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice. Saka M, et al. J Neurosurg, 2010 Aug. PMID 19895199

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
      Title: Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
    2. IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway.
      Title: IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway.
    3. Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis.
      Title: Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis.
    4. Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterusdagger.
      Title: Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†.
    5. Unique IL-13Ralpha2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination.
      Title: Unique IL-13Rα2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination.
    6. Study in Il13ra2 knockout and wild type mice exposed to dextran sodium sulfate to induce inflammatory bowel disease (IBD) suggest that Il13ra2 on epithelial cells contributes to IBD pathology by negatively influencing goblet cell recovery, goblet cell function and epithelial restoration after injury.
      Title: Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease.
    7. Upon lipopolysaccharide stimulation, macrophage Raw 264.7 cells showed elevated IL-13R-alpha-2 expression via immunofluorescence staining and increased MRI probe binding via built-in TAMRA fluorescence imaging. for the first time, IL-13R-alpha-2 was investigated as a unique biomarker in the context of osteomyelitis.
      Title: Detecting Chronic Post-Traumatic Osteomyelitis of Mouse Tibia via an IL-13Rα2 Targeted Metallofullerene Magnetic Resonance Imaging Probe.
    8. Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway.
      Title: IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer.
    9. overexpression of IL-13Ra2 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis.
      Title: Modulation of pulmonary fibrosis by IL-13Rα2.
    10. data collectively support a distinct role for membrane IL-13Ralpha2 in the lung and suggest that memIL-13Ralpha2 might contribute to allergic inflammation
      Title: IL-13 receptor α2 contributes to development of experimental allergic asthma.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-13 receptor subunit alpha-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306059.1 → NP_001292988.1  interleukin-13 receptor subunit alpha-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001292988.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL662932, AL807780, BX005200
      UniProtKB/Swiss-Prot
      O88786
      Conserved Domains (1) summary
      pfam09240
      Location:136 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    2. NM_008356.4 → NP_032382.1  interleukin-13 receptor subunit alpha-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL662932, AL807780, BX005200
      Consensus CDS
      CCDS30460.1
      UniProtKB/Swiss-Prot
      A3F812, O88786, Q3V2V5
      Related
      ENSMUSP00000033646.3, ENSMUST00000033646.9
      Conserved Domains (1) summary
      pfam09240
      Location:136 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      146166474..146214982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528707.4 → XP_006528770.1  interleukin-13 receptor subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_006528770.1

      UniProtKB/Swiss-Prot
      A3F812, O88786, Q3V2V5
      Related
      ENSMUSP00000108446.2, ENSMUST00000112827.2
      Conserved Domains (1) summary
      pfam09240
      Location:136 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    2. XM_030251234.2 → XP_030107094.1  interleukin-13 receptor subunit alpha-2 isoform X2

      Conserved Domains (1) summary
      pfam09240
      Location:136 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    3. XM_017318395.2 → XP_017173884.1  interleukin-13 receptor subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      O88786
      Conserved Domains (1) summary
      pfam09240
      Location:136 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    4. XM_036161826.1 → XP_036017719.1  interleukin-13 receptor subunit alpha-2 isoform X1

      UniProtKB/Swiss-Prot
      A3F812, O88786, Q3V2V5
      Conserved Domains (1) summary
      pfam09240
      Location:136 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    5. XM_006528708.4 → XP_006528771.1  interleukin-13 receptor subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_006528771.1

      UniProtKB/Swiss-Prot
      A3F812, O88786, Q3V2V5
      Conserved Domains (1) summary
      pfam09240
      Location:136 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88786.1 GenPept UniProtKB/Swiss-Prot:O88786

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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