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    Il11 interleukin 11 [ Mus musculus (house mouse) ]

    Gene ID: 16156, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Il11provided by MGI
    Official Full Name
    interleukin 11provided by MGI
    Primary source
    MGI:MGI:107613
    See related
    Ensembl:ENSMUSG00000004371 AllianceGenome:MGI:107613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-11
    Summary
    Enables cytokine activity and interleukin-11 receptor binding activity. Acts upstream of or within positive regulation of cell population proliferation. Located in cytoplasm. Orthologous to human IL11 (interleukin 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 3.5), colon adult (RPKM 0.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 2.76 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4775372..4785877, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4772373..4782907, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene transmembrane protein 190 Neighboring gene transmembrane protein 238 Neighboring gene STARR-positive B cell enhancer ABC_E6507 Neighboring gene predicted gene, 57780 Neighboring gene ribosomal protein L28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome. Ng B, et al. Arterioscler Thromb Vasc Biol, 2023 May. PMID 36924234, Free PMC Article
    2. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo. Ma J, et al. J Environ Sci (China), 2023 Apr. PMID 36503802
    3. Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis. Dong B, et al. Nat Commun, 2022 Nov 23. PMID 36424386, Free PMC Article
    4. MEK/ERK/RUNX2 Pathway-Mediated IL-11 Autocrine Promotes the Activation of Müller Glial Cells during Diabetic Retinopathy. Ji N, et al. Curr Eye Res, 2022 Dec. PMID 36154781
    5. IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis. Ng B, et al. Int J Mol Sci, 2022 Mar 24. PMID 35408908, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.
      Title: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.
    2. Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing.
      Title: Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing.
    3. Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.
      Title: Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.
    4. The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis.
      Title: The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis.
    5. Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.
      Title: Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.
    6. IL11 activates the placental inflammasome to drive preeclampsia.
      Title: IL11 activates the placental inflammasome to drive preeclampsia.
    7. IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome.
      Title: IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome.
    8. IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.
      Title: IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.
    9. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo.
      Title: Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo.
    10. Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.
      Title: Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables interleukin-11 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-11-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290423.2 → NP_001277352.1  interleukin-11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-5 all encode the same isoform (2).
      Source sequence(s)
      AC162034
      Consensus CDS
      CCDS71881.1
      UniProtKB/TrEMBL
      F7A7F2
      Related
      ENSMUSP00000131168.3, ENSMUST00000163481.3
      Conserved Domains (1) summary
      pfam07400
      Location:2 → 140
      IL11; Interleukin 11

    2. NM_001412482.1 → NP_001399411.1  interleukin-11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162034
      UniProtKB/TrEMBL
      F7A7F2
      Related
      ENSMUSP00000157240.2, ENSMUST00000234277.2

    3. NM_001412483.1 → NP_001399412.1  interleukin-11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162034
      UniProtKB/TrEMBL
      F7A7F2

    4. NM_001412484.1 → NP_001399413.1  interleukin-11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162034
      UniProtKB/TrEMBL
      F7A7F2

    5. NM_008350.5 → NP_032376.1  interleukin-11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032376.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC162034
      Consensus CDS
      CCDS39740.1
      UniProtKB/Swiss-Prot
      P47873
      UniProtKB/TrEMBL
      A3KPB8, Q3V0U3
      Related
      ENSMUSP00000092492.6, ENSMUST00000094892.12
      Conserved Domains (1) summary
      pfam07400
      Location:23 → 199
      IL11; Interleukin 11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4775372..4785877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152699.1 → XP_036008592.1  interleukin-11 isoform X1

      UniProtKB/TrEMBL
      F7A7F2
      Conserved Domains (1) summary
      pfam07400
      Location:2 → 140
      IL11; Interleukin 11

    2. XM_017321988.3 → XP_017177477.1  interleukin-11 isoform X2

      Conserved Domains (1) summary
      pfam07400
      Location:2 → 145
      IL11; Interleukin 11
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47873.1 GenPept UniProtKB/Swiss-Prot:P47873

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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