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    Igfals insulin-like growth factor binding protein, acid labile subunit [ Mus musculus (house mouse) ]

    Gene ID: 16005, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Igfalsprovided by MGI
    Official Full Name
    insulin-like growth factor binding protein, acid labile subunitprovided by MGI
    Primary source
    MGI:MGI:107973
    See related
    Ensembl:ENSMUSG00000046070 AllianceGenome:MGI:107973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALS; Albs
    Summary
    Predicted to enable Roundabout binding activity; heparin binding activity; and insulin-like growth factor binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region. Predicted to be part of insulin-like growth factor ternary complex. Is expressed in ductus deferens; epididymis; and testis. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 141.0), subcutaneous fat pad adult (RPKM 33.1) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Igfals in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25096818..25100985)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24877844..24882011)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene meiosis specific with OB domains Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene predicted gene, 41549 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth. Liu Z, et al. Endocrinology, 2017 Aug 1. PMID 28475811, Free PMC Article
    2. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Kennedy OD, et al. Endocrinology, 2014 Mar. PMID 24424061, Free PMC Article
    3. The acid-labile subunit is required for full effects of exogenous growth hormone on growth and carbohydrate metabolism. Ueki I, et al. Endocrinology, 2009 Jul. PMID 19299456, Free PMC Article
    4. Overexpression of the acid-labile subunit of the IGF ternary complex in transgenic mice. Silha JV, et al. Endocrinology, 2001 Oct. PMID 11564688
    5. Regulation and role of the acid-labile subunit of the 150-kilodalton insulin-like growth factor complex in the mouse. Boisclair YR, et al. Pediatr Nephrol, 2000 Jul. PMID 10912519

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Igfals gene has a role in skeletal response of male mice to anabolic hormone therapy
      Title: Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene.
    2. A modest reduction in post-natal growth in the null ALS mice and in the ALS-deficient patients was observed
      Title: Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA4111, MGC150140, MGC150141

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Roundabout binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of insulin-like growth factor ternary complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein complex acid labile subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364895.1 → NP_001351824.1  insulin-like growth factor-binding protein complex acid labile subunit isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/Swiss-Prot
      P70389, Q9DBI7
      UniProtKB/TrEMBL
      Q791Q5
      Conserved Domains (4) summary
      smart00013
      Location:40 → 78
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:124 → 147
      LRR_RI; leucine-rich repeat [structural motif]
      cl15307
      Location:535 → 578
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl26793
      Location:61 → 523
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    2. NM_001364896.1 → NP_001351825.1  insulin-like growth factor-binding protein complex acid labile subunit isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/TrEMBL
      Q570Z9
      Conserved Domains (4) summary
      smart00013
      Location:75 → 113
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:159 → 182
      LRR_RI; leucine-rich repeat [structural motif]
      cl15307
      Location:570 → 613
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl26793
      Location:96 → 558
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    3. NM_008340.4 → NP_032366.2  insulin-like growth factor-binding protein complex acid labile subunit isoform 1 precursor

      See identical proteins and their annotated locations for NP_032366.2

      Status: VALIDATED

      Source sequence(s)
      AC166102, AK004926, BP768883
      Consensus CDS
      CCDS37497.1
      UniProtKB/Swiss-Prot
      P70389, Q9DBI7
      UniProtKB/TrEMBL
      A0A0R4J0S2, Q791Q5
      Related
      ENSMUSP00000060169.7, ENSMUST00000050714.8
      Conserved Domains (5) summary
      smart00013
      Location:40 → 78
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:277 → 537
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:124 → 147
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:219 → 278
      LRR_8; Leucine rich repeat
      cl15307
      Location:535 → 578
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25096818..25100985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70389.1 GenPept UniProtKB/Swiss-Prot:P70389

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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