Ifrd1 interferon-related developmental regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifrd1provided by MGI
Official Full Name: interferon-related developmental regulator 1provided by MGI
Primary source: MGI:MGI:1316717
See related: Ensembl:ENSMUSG00000001627 AllianceGenome:MGI:1316717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PC4; Ifnl; Tis7
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including muscle cell differentiation; negative regulation of axonogenesis; and skeletal muscle tissue regeneration. Located in cytoplasm and nucleus. Is expressed in several structures, including extraembryonic component; liver and biliary system; nasal cavity epithelium; nervous system; and tooth. Orthologous to human IFRD1 (interferon related developmental regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in small intestine adult (RPKM 45.7), duodenum adult (RPKM 33.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B1; 12 18.06 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (40253128..40273184, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (40203129..40223189, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
Title: The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15).
IFRD1 regulates the asthmatic responses of airway via NF-kappaB pathway.
Title: IFRD1 regulates the asthmatic responses of airway via NF-κB pathway.
findings reveal that oridonin protects against OVX-induced bone loss via inhibiting osteoclastic bone resorption but enhancing osteoblastic bone formation through abolishing both Ifrd1-mediating and IkappaBalpha-mediated p65 nuclear translocation.
Title: A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-Mediated and IκBα-Mediated p65 Nuclear Translocation.
Ifrd1 is a critical mediator of both osteoblastogenesis and osteoclastogenesis through its expression in osteoblasts.
Title: [Transcription Regulators and Bone Metabolism].
Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.
Title: Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.
adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Title: The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes.
These results suggest that BMP-2 directly induces Ifrd1 expression at the transcriptional level in osteoblasts via the Smad pathway, and Ifrd1 negatively regulates BMP-2-dependent osteoblastogenesis.
Title: The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.
Ifrd1 has a pivotal role in bone homeostasis through its expression in osteoblasts in vivo and represents a therapeutic target for bone diseases.
Title: The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.
High-fat diet feeding in the setting of tis7 deletion resulted in postresection anastomotic inflammation and small bowel obstruction.
Title: Tis7 deletion reduces survival and induces intestinal anastomotic inflammation and obstruction in high-fat diet-fed mice with short bowel syndrome.
TIS7 predominantly interacted with beta-catenin in the nucleus.
Title: Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ifrd1 (e-PCR), detects polymorphism
- UniSTS:143463

NoName (e-PCR)
- UniSTS:224744

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of collateral sprouting	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striated muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon-related developmental regulator 1

Names: TPA-induced sequence 7; nerve growth factor-inducible protein PC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013562.3 → NP_038590.2 interferon-related developmental regulator 1

See identical proteins and their annotated locations for NP_038590.2

Status: VALIDATED

Source sequence(s)

AC157571, AC174598

Consensus CDS

CCDS25893.1

UniProtKB/Swiss-Prot

P19182, P21835, P70228, Q80XM4

UniProtKB/TrEMBL

E9PVS0

Related

ENSMUSP00000001672.6, ENSMUST00000001672.12

Conserved Domains (2) summary

pfam04836
Location:390 → 443

IFRD_C; Interferon-related protein conserved region

pfam05004
Location:40 → 344

IFRD; Interferon-related developmental regulator (IFRD)

RNA

NR_181992.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC157571, AC174598
NR_181993.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC157571, AC174598
NR_181994.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC157571, AC174598
NR_181995.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC157571, AC174598
NR_181996.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC157571, AC174598