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    Idh1 isocitrate dehydrogenase 1 (NADP+), soluble [ Mus musculus (house mouse) ]

    Gene ID: 15926, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Idh1provided by MGI
    Official Full Name
    isocitrate dehydrogenase 1 (NADP+), solubleprovided by MGI
    Primary source
    MGI:MGI:96413
    See related
    Ensembl:ENSMUSG00000025950 AllianceGenome:MGI:96413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Id-1; Idpc; Idh-1; E030024J03Rik
    Summary
    Enables isocitrate dehydrogenase (NADP+) activity. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 104.0), CNS E18 (RPKM 83.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Idh1 in Genome Data Viewer
    Location:
    1 C2- C3; 1 32.91 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65197775..65225638, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65158616..65186479, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630023F18 gene Neighboring gene STARR-seq mESC enhancer starr_01174 Neighboring gene crystallin, gamma A Neighboring gene STARR-seq mESC enhancer starr_01175 Neighboring gene predicted gene, 36358 Neighboring gene STARR-seq mESC enhancer starr_01176 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65224921-65225030 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:65225772-65225881 Neighboring gene STARR-positive B cell enhancer ABC_E5765 Neighboring gene phosphoinositide kinase, FYVE type zinc finger containing Neighboring gene STARR-positive B cell enhancer ABC_E5766 Neighboring gene STARR-seq mESC enhancer starr_01177 Neighboring gene parathyroid hormone 2 receptor Neighboring gene STARR-seq mESC enhancer starr_01178 Neighboring gene STARR-seq mESC enhancer starr_01179

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutant IDH1 attenuates hepatic lipogenesis through PTEN dependent pathway. Zhao Q. Biochem Biophys Res Commun, 2022 Dec 31. PMID 36410274
    2. Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair. Dow J, et al. Mol Cancer Res, 2021 Dec. PMID 34535560, Free PMC Article
    3. IDH1 mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis. Gu Y, et al. Blood, 2021 Feb 18. PMID 33254233
    4. Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma. Yang R, et al. Oncogene, 2020 Oct. PMID 32855525
    5. Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E. Zhang Y, et al. Cancer Res, 2019 Oct 1. PMID 31391185, Free PMC Article

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
      Title: Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia.
    2. IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
      Title: IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
    3. Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
      Title: Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
    4. Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
      Title: Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
    5. HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.
      Title: HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.
    6. Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
      Title: Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
    7. Mutant IDH Inhibits IFNgamma-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
      Title: Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
    8. Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair.
      Title: Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair.
    9. Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/alpha-KG-mediated glycolysis.
      Title: Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.
    10. Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.
      Title: Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC115782

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isocitrate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isocitrate dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isocitrate dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isocitrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of phospholipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NADP] cytoplasmic
    Names
    IDH
    IDP
    NADP(+)-specific ICDH
    cytosolic NADP-isocitrate dehydrogenase
    oxalosuccinate decarboxylase
    NP_001104790.1
    NP_034627.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111320.1 → NP_001104790.1  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_001104790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK167158, BY787507, CF379827, CF950262
      Consensus CDS
      CCDS15016.1
      UniProtKB/Swiss-Prot
      O88844, Q3UAV7
      UniProtKB/TrEMBL
      Q3TJ51, Q5HZJ8
      Related
      ENSMUSP00000127307.2, ENSMUST00000169032.8
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    2. NM_010497.3 → NP_034627.3  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_034627.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK167158, BB868400, CF379827
      Consensus CDS
      CCDS15016.1
      UniProtKB/Swiss-Prot
      O88844, Q3UAV7
      UniProtKB/TrEMBL
      Q3TJ51, Q5HZJ8
      Related
      ENSMUSP00000095316.5, ENSMUST00000097709.11
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65197775..65225638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88844.2 GenPept UniProtKB/Swiss-Prot:O88844

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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