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    Htr5b 5-hydroxytryptamine (serotonin) receptor 5B [ Mus musculus (house mouse) ]

    Gene ID: 15564, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Htr5bprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 5Bprovided by MGI
    Primary source
    MGI:MGI:96284
    See related
    Ensembl:ENSMUSG00000050534 AllianceGenome:MGI:96284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5-Ht5b
    Summary
    Enables G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; eye; incisor; and male reproductive gland or organ. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 3.1), genital fat pad adult (RPKM 0.7) and 4 other tissues See more
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    Genomic context

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    Location:
    1 E2.3; 1 52.98 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (121437487..121458351, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (121509758..121529312, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10030 Neighboring gene predicted gene, 35243 Neighboring gene coiled-coil domain containing 93 Neighboring gene STARR-seq mESC enhancer starr_02076 Neighboring gene STARR-seq mESC enhancer starr_02077 Neighboring gene DEAD box helicase 18 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:123504681-123504864 Neighboring gene STARR-seq mESC enhancer starr_02078 Neighboring gene STARR-seq mESC enhancer starr_02080 Neighboring gene STARR-seq mESC enhancer starr_02081 Neighboring gene STARR-seq mESC enhancer starr_02082 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior. Yoshida K, et al. Nat Neurosci, 2019 May. PMID 30988523
    2. Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents. Tainaka K, et al. Cell Rep, 2018 Aug 21. PMID 30134179
    3. Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice. Vogelgesang S, et al. Front Mol Neurosci, 2018. PMID 29515365, Free PMC Article
    4. Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI. Takata N, et al. PLoS One, 2015. PMID 25793741, Free PMC Article
    5. Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. Maekawa T, et al. EMBO J, 2010 Jan 6. PMID 19893493, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei.
      Title: Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141198

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 5B
    Names
    5-HT-5B
    protein-tyrosine-phosphatase (EC 3.1.3.48) Ly-5 precursor (B-cell variant)
    serotonin receptor 5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010483.3 → NP_034613.2  5-hydroxytryptamine receptor 5B

      See identical proteins and their annotated locations for NP_034613.2

      Status: VALIDATED

      Source sequence(s)
      AC111011
      Consensus CDS
      CCDS15239.1
      UniProtKB/Swiss-Prot
      P31387, Q1RME2
      UniProtKB/TrEMBL
      G3X9C6
      Related
      ENSMUSP00000057212.8, ENSMUST00000055884.8
      Conserved Domains (1) summary
      pfam00001
      Location:69 → 351
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      121437487..121458351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317180.2 → XP_017172669.1  5-hydroxytryptamine receptor 5B isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:87 → 113
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:65 → 241
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31387.1 GenPept UniProtKB/Swiss-Prot:P31387

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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