Hspa2 heat shock protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspa2provided by MGI
Official Full Name: heat shock protein 2provided by MGI
Primary source: MGI:MGI:96243
See related: Ensembl:ENSMUSG00000059970 AllianceGenome:MGI:96243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 70kDa; HSP70.2; HSP70A2; Hsp70-2
Summary: Enables glycolipid binding activity. Involved in positive regulation of ATPase activity; positive regulation of ATPase-coupled calcium transmembrane transporter activity; and spermatogenesis. Acts upstream of or within several processes, including male gamete generation; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Located in cell surface; meiotic spindle; and nucleus. Part of CatSper complex. Is expressed in alimentary system; ganglia; medulla oblongata basal plate; testis; and vibrissa. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 333.5), bladder adult (RPKM 20.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 33.73 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (76450688..76453712)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (76403812..76406938)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.
Title: Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.
Proteolytic degradation of Hspa2 occurs in response to oxidative stress mediated by 4-hydroxynonenal in male germ cells of the mouse.
Title: Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse.
a candidate gene approach revealed that HSPA2 is a prominent molecular target of ELAVL1
Title: The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages.
NASP controls the ability of HSPA2 to activate CDC2 for CDC2/cyclin B1 complex formation.
Title: Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse.
Hspa2 was detected in central and peripheral nervous system: in neuron's bodies and fiber tracts, in the subventricular zone of the lateral ventricles, in the dentate gyrus of the hippocampus, in enteric ganglia of the gastrointestinal tract
Title: The expression pattern of the 70-kDa heat shock protein Hspa2 in mouse tissues.
Data show that Parp2 interacts significantly with both the transition protein TP2 and the transition chaperone HSPA2, whereas Parp1 binds weakly to HSPA2.
Title: Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.
Bat3 is identified as a critical regulator of Hsp70-2 in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility.
Title: Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis.
high-level testis-specific gene expression requires additional sequences localized upstream of the T2 transcription start site
Title: Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene.
Data show that NFAT5/TonEBP stimulates transcription of HSP70-2, and is a master regulator of the renal medulla for cellular protection against high osmolality via organic osmolytes and molecular chaperones.
Title: TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity.
Role of Hsp70.2/Hst70 gene in development of the nervous system.
Title: Promoter of the heat shock testis-specific Hsp70.2/Hst70 gene is active in nervous system during embryonic development of mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

mHspa2 (e-PCR)
- UniSTS:514580

Hspa2 (e-PCR), detects polymorphism
- UniSTS:498762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables glycolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP-dependent activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptonemal complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CatSper complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock-related 70 kDa protein 2

Names: heat shock 70kDa protein 2; heat shock protein 70.2; heat shock protein, 70 kDa 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002012.2 → NP_001002012.1 heat shock-related 70 kDa protein 2

See identical proteins and their annotated locations for NP_001002012.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence and encodes the same protein, as compared to variant 1.

Source sequence(s)

BC052350

Consensus CDS

CCDS25993.1

UniProtKB/Swiss-Prot

P17156, Q99KD7

UniProtKB/TrEMBL

B7U582

Related

ENSMUSP00000079306.6, ENSMUST00000080449.7

Conserved Domains (1) summary

PTZ00009
Location:2 → 615

PTZ00009; heat shock 70 kDa protein; Provisional
NM_001409571.1 → NP_001396500.1 heat shock-related 70 kDa protein 2

Status: VALIDATED

Source sequence(s)

AC124453

UniProtKB/Swiss-Prot

P17156, Q99KD7
NM_001409572.1 → NP_001396501.1 heat shock-related 70 kDa protein 2

Status: VALIDATED

Source sequence(s)

AC124453

UniProtKB/Swiss-Prot

P17156, Q99KD7
NM_008301.5 → NP_032327.2 heat shock-related 70 kDa protein 2

See identical proteins and their annotated locations for NP_032327.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.

Source sequence(s)

AK132261, BC052350

Consensus CDS

CCDS25993.1

UniProtKB/Swiss-Prot

P17156, Q99KD7

UniProtKB/TrEMBL

B7U582

Related

ENSMUSP00000151408.2, ENSMUST00000219555.2

Conserved Domains (1) summary

PTZ00009
Location:2 → 615

PTZ00009; heat shock 70 kDa protein; Provisional