Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsd11b2provided by MGI
Official Full Name: hydroxysteroid 11-beta dehydrogenase 2provided by MGI
Primary source: MGI:MGI:104720
See related: Ensembl:ENSMUSG00000031891 AllianceGenome:MGI:104720
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 11HSD2
Summary: Predicted to enable NAD binding activity and steroid binding activity. Acts upstream of or within female pregnancy. Predicted to be located in cytoplasm; lipid droplet; and nucleoplasm. Is expressed in several structures, including adrenal gland; ear; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 298.3), kidney adult (RPKM 127.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106245378..106250620)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105518746..105523988)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study presents predicted binding mode of 7-oxygenated 25-hydroxycholesterols in the binding pocket of murine 11HSD2.
Title: Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.
A subset of HSD2 neurons may promote the dysphoric, anorexic, and anhedonic symptoms of hyperaldosteronism via AgRP-inhibited relay neurons in the parabrachial complex.
Title: Aldosterone-sensitive HSD2 neurons in mice.
Kidney-specific deficiency of 11beta-HSD2 leads to Salt-dependent Hypertension, which is attributed to mineralocorticoid receptor-epithelial sodium channel-Na(+)-Cl(-) cotransporter activation in the kidney.
Title: Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent Hypertension.
Rac1 GTPase regulates 11beta-HSD2 expression, mineralocorticoid receptor activation, and mineralocorticoid receptor-mediated pro-fibrotic signaling.
Title: Rac1 GTPase regulates 11β hydroxysteroid dehydrogenase type 2 and fibrotic remodeling.
Nr3c2 has a role in mouse skin development in a process that involves HSD11B1/HSD11B2
Title: The mineralocorticoid receptor plays a transient role in mouse skin development.
Reduced brain 11betaHSD2 promotes a hunger for salt and salt sensitivity. 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor-dependent pathway.
Title: Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.
11betaHSD2 inhibition suppressed lung tumor growth and invasion in association with increased tissue active glucocorticoid levels, decreased COX-2 expression, inhibition of ERK and mTOR signaling pathways.
Title: Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways.
placental 11bHSD2 expression is significantly reduced in pregnancies complicated by intrahepatic cholestasis of pregnancy.
Title: Cholestatic pregnancy is associated with reduced placental 11βHSD2 expression.
results show that intestinal epithelial 11ssHSD2 activity contributes to increased COX-2 expression in Apc+/min intestinal adenomas and that 11ssHSD2 deficiency in intestinal epithelial cells suppresses adenoma development and growth
Title: Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis.
11beta-hydroxysteroid dehydrogenase-2 is a cortisol-inactivating enzyme with a role in keratinocyte cell proliferation and basal cell proliferation
Title: Expression profiles of cortisol-inactivating enzyme, 11β-hydroxysteroid dehydrogenase-2, in human epidermal tumors and its role in keratinocyte proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables steroid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cortisol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucocorticoid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucocorticoid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood volume by renal aldosterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 11-beta-hydroxysteroid dehydrogenase type 2

Names: 11-DH2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2

NP_032315.2

EC 1.1.1.146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008289.2 → NP_032315.2 11-beta-hydroxysteroid dehydrogenase type 2

See identical proteins and their annotated locations for NP_032315.2

Status: VALIDATED

Source sequence(s)

AC151573, BB618868, BC066209

Consensus CDS

CCDS40460.1

UniProtKB/Swiss-Prot

P51661, Q91WK3

UniProtKB/TrEMBL

Q3U2R0

Related

ENSMUSP00000034363.6, ENSMUST00000034363.7

Conserved Domains (2) summary

cd09805
Location:83 → 363

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:83 → 278

adh_short; short chain dehydrogenase