Hrh1 histamine receptor H1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hrh1provided by MGI
Official Full Name: histamine receptor H1provided by MGI
Primary source: MGI:MGI:107619
See related: Ensembl:ENSMUSG00000053004 AllianceGenome:MGI:107619
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H1R; Hir; Bphs; HH1R
Summary: Predicted to enable several functions, including G protein-coupled serotonin receptor activity; calcium ion transmembrane transporter activity; and histamine binding activity. Acts upstream of or within memory; regulation of synaptic plasticity; and visual learning. Predicted to be located in cytosol and plasma membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; stomach; and uterus. Orthologous to human HRH1 (histamine receptor H1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 2.2), colon adult (RPKM 1.7) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 53.05 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (114374897..114459432)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (114397936..114483298)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of Histamine-H1R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFkappaB-p65 pathway.
Title: Disruption of Histamine-H(1)R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFκB-p65 pathway.
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
Title: TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
Title: The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization
Title: The effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization.
Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons.
Title: A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H(1) receptors.
Study showed that the sleep-wake cycle in H1-/- mice was affected both quantitatively and qualitatively: long-term abolition of histamine impairs cortical EEG, affects sleep-wake qualities and causes sleepiness facing behavioral challenges
Title: Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.
this study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy
Title: The antihistamine olopatadine regulates T cell activation in palladium allergy.
Sympathetic tone changed in H1R-, but not H2R- or H3R-null mice.
Title: Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity.
The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory.
Title: Impaired spatial learning and reduced adult hippocampal neurogenesis in histamine H1-receptor knockout mice.
These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation.
Title: Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hrh1 (e-PCR), detects polymorphism
- UniSTS:164924

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables histamine binding	ISO Inferred from Sequence Orthology more info
enables histamine receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion import	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to histamine	ISO Inferred from Sequence Orthology more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within manganese ion transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histamine H1 receptor

Names: Bordetella pertussis induced histamine sensitization

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252642.3 → NP_001239571.1 histamine H1 receptor

See identical proteins and their annotated locations for NP_001239571.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.

Source sequence(s)

AC159381

Consensus CDS

CCDS20435.1

UniProtKB/Swiss-Prot

P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3

UniProtKB/TrEMBL

B3Y5T0

Related

ENSMUSP00000124460.2, ENSMUST00000161650.3

Conserved Domains (1) summary

cd15050
Location:29 → 480

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001252643.3 → NP_001239572.1 histamine H1 receptor

See identical proteins and their annotated locations for NP_001239572.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.

Source sequence(s)

AC159381

Consensus CDS

CCDS20435.1

UniProtKB/Swiss-Prot

P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3

UniProtKB/TrEMBL

B3Y5T0

Related

ENSMUSP00000124037.2, ENSMUST00000161220.2

Conserved Domains (1) summary

cd15050
Location:29 → 480

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001317124.2 → NP_001304053.1 histamine H1 receptor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.

Source sequence(s)

AC159381

Consensus CDS

CCDS20435.1

UniProtKB/Swiss-Prot

P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3

UniProtKB/TrEMBL

B3Y5T0

Related

ENSMUSP00000124320.2, ENSMUST00000160780.2

Conserved Domains (1) summary

cd15050
Location:29 → 480

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001317125.2 → NP_001304054.1 histamine H1 receptor

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.

Source sequence(s)

AC159381

Consensus CDS

CCDS20435.1

UniProtKB/Swiss-Prot

P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3

UniProtKB/TrEMBL

B3Y5T0

Conserved Domains (1) summary

cd15050
Location:29 → 480

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001317126.2 → NP_001304055.1 histamine H1 receptor

Status: VALIDATED

Description

Transcript Variant: This variant (6) represents the longest transcript. Variants 1 thorugh 6 encode the same protein.

Source sequence(s)

AC159381

Consensus CDS

CCDS20435.1

UniProtKB/Swiss-Prot

P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3

UniProtKB/TrEMBL

B3Y5T0

Conserved Domains (1) summary

cd15050
Location:29 → 480

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001410031.1 → NP_001396960.1 histamine H1 receptor

Status: VALIDATED

Source sequence(s)

AC159381

UniProtKB/Swiss-Prot

P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3

UniProtKB/TrEMBL

B3Y5T0
NM_008285.5 → NP_032311.2 histamine H1 receptor

See identical proteins and their annotated locations for NP_032311.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.

Source sequence(s)

AC159381

Consensus CDS

CCDS20435.1

UniProtKB/Swiss-Prot

P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3

UniProtKB/TrEMBL

B3Y5T0

Related

ENSMUSP00000086383.3, ENSMUST00000088987.3

Conserved Domains (1) summary

cd15050
Location:29 → 480

7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors