Lipc lipase, hepatic [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lipcprovided by MGI
Official Full Name: lipase, hepaticprovided by MGI
Primary source: MGI:MGI:96216
See related: Ensembl:ENSMUSG00000032207 AllianceGenome:MGI:96216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HL; Hpl
Summary: Enables lipase activity. Acts upstream of or within cholesterol homeostasis; cholesterol metabolic process; and cholesterol transport. Located in extracellular space. Is expressed in liver and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 48.1), liver E18 (RPKM 35.8) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 39.57 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (70705410..70859503, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (70798128..70952221, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
Title: Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas.
Title: Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin β-Receptor pathway.
hepatic lipase KO mice had dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. Also glucose intolerance, pancreatic and hepatic inflammation and steatosis.
Title: Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis.
Bone marrow (BM)-derived hepatic lipase mitigates the HDL-lowering, HDL-modulating, and cholesterol-raising effects of BM-derived cholesteryl ester transfer protein.
Title: Bone marrow-derived HL mitigates bone marrow-derived CETP-mediated decreases in HDL in mice globally deficient in HL and the LDLr.
HL expressed by osteoblasts has an impact on osteoblast OPG expression and that lack of HL leads to increased bone mass.
Title: Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity.
Hepatic lipase and endothelial lipase influence molecular species of several classes of plasma lipids.
Title: Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.
interaction of LIGHT with LTbetaR on hepatocytes, but not Kupffer cells, is sufficient to down regulate hepatic lipase expression and that this effect can be independent of LIGHT's costimulatory function.
Title: LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells.
Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
Title: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
Data show a novel pathway involving HL hydrolysis of VLDL that activates PPARdelta through generation of specific monounsaturated fatty acids.
Title: VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses.
These results demonstrated that fatty acid synthase and hepatic lipase might be FXR-regulated genes in liver cells.
Title: Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lipc (e-PCR), detects polymorphism
- UniSTS:546844

RH136292 (e-PCR)
- UniSTS:210285

NoName (e-PCR)
- UniSTS:237704

AI256194 (e-PCR)
- UniSTS:179926

RH125770 (e-PCR)
- UniSTS:162519

RH94786 (e-PCR)
- UniSTS:120033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables acetylesterase activity	ISO Inferred from Sequence Orthology more info
enables acylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	IBA Inferred from Biological aspect of Ancestor more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables chylomicron binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info
enables triglyceride lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remodeling	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in neutral lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of plasma lipoprotein particle levels	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hepatic triacylglycerol lipase

Names: hepatic lipase; lipase member C; lysophospholipase; phospholipase A1

NP_001311401.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

NP_001311402.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

NP_001398716.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

NP_001398717.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

NP_001398718.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

NP_032306.2

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

XP_006510880.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

XP_006510881.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

XP_036010505.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324472.1 → NP_001311401.1 hepatic triacylglycerol lipase isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

BC021841, BY337256

Consensus CDS

CCDS23324.1

UniProtKB/Swiss-Prot

P27656, Q8VC44

Conserved Domains (2) summary

cd01758
Location:353 → 488

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:18 → 350

Lipase
NM_001324473.1 → NP_001311402.1 hepatic triacylglycerol lipase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. Variant 3 is predicted to encode a protein (isoform 2) which lacks the signal peptide that is present in isoform 1.

Source sequence(s)

BC021841, BY337256

Consensus CDS

CCDS90617.1

UniProtKB/TrEMBL

Q3TYU0

Related

ENSMUSP00000149185.2, ENSMUST00000216798.2

Conserved Domains (3) summary

cd00707
Location:1 → 261

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01758
Location:268 → 403

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:1 → 265

Lipase; Lipase
NM_001411787.1 → NP_001398716.1 hepatic triacylglycerol lipase isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC137843, CT025701

UniProtKB/Swiss-Prot

P27656, Q8VC44
NM_001411788.1 → NP_001398717.1 hepatic triacylglycerol lipase isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC137843, CT025701
NM_001411789.1 → NP_001398718.1 hepatic triacylglycerol lipase isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC137843, CT025701
NM_008280.2 → NP_032306.2 hepatic triacylglycerol lipase isoform 1 precursor

See identical proteins and their annotated locations for NP_032306.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

BC021841

Consensus CDS

CCDS23324.1

UniProtKB/Swiss-Prot

P27656, Q8VC44

Related

ENSMUSP00000034731.9, ENSMUST00000034731.10

Conserved Domains (2) summary

cd01758
Location:353 → 488

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:18 → 350

Lipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

70705410..70859503 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154612.1 → XP_036010505.1 hepatic triacylglycerol lipase isoform X3

Conserved Domains (2) summary

cd01758
Location:284 → 419

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:1 → 281

Lipase
XM_006510817.3 → XP_006510880.1 hepatic triacylglycerol lipase isoform X3

Conserved Domains (2) summary

cd01758
Location:284 → 419

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:1 → 281

Lipase
XM_006510818.4 → XP_006510881.1 hepatic triacylglycerol lipase isoform X4

Conserved Domains (1) summary

pfam00151
Location:18 → 366

Lipase