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    Hoxc8 homeobox C8 [ Mus musculus (house mouse) ]

    Gene ID: 15426, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hoxc8provided by MGI
    Official Full Name
    homeobox C8provided by MGI
    Primary source
    MGI:MGI:96198
    See related
    Ensembl:ENSMUSG00000001657 AllianceGenome:MGI:96198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hox-3.1; D130011F21Rik
    Summary
    Enables DNA binding activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; integumental system; and nervous system. Orthologous to human HOXC8 (homeobox C8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 8.3), subcutaneous fat pad adult (RPKM 6.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hoxc8 in Genome Data Viewer
    Location:
    15 F3; 15 58.05 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102898971..102902707)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102990539..102994275)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene microRNA 196a-2 Neighboring gene homeobox C9 Neighboring gene predicted gene, 36878 Neighboring gene predicted gene, 29905 Neighboring gene homeobox C6 Neighboring gene STARR-seq mESC enhancer starr_39862

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vitro osteoblast differentiation is negatively regulated by Hoxc8. Zheng YJ, et al. Appl Biochem Biotechnol, 2010 Mar. PMID 19214787
    2. Morpholino-mediated knockdown in primary chondrocytes implicates Hoxc8 in regulation of cell cycle progression. Kamel S, et al. Bone, 2009 Apr. PMID 19071237, Free PMC Article
    3. The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cells. Kong KA, et al. Biochem Biophys Res Commun, 2008 Dec 5. PMID 18835255
    4. Multiple roles of hoxc8 in skeletal development. Juan AH, et al. Ann N Y Acad Sci, 2006 Apr. PMID 16831908
    5. Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells. Lei H, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16793922, Free PMC Article

    See all (169) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5, HoxC4 &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin down regulates HoxA10. T3 results in over expression of HoxA5, HoxC4 and HoxC8 genes, whereas insulin up regulates expression of only HoxC8
      Title: Fat accumulation in differentiated brown adipocytes is linked with expression of Hox genes.
    2. Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/beta-catenin signaling
      Title: Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling.
    3. Cdx1 regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation.
      Title: Cdx1 is essential for the initiation of HoxC8 expression during early embryogenesis.
    4. Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
      Title: Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
    5. Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4-transgenic mice.
      Title: Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice.
    6. Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 promoter activity and its mRNA expression
      Title: Hoxc8 represses BMP-induced expression of Smad6.
    7. Hoxc8 regulation is essential for osteoblast differentiation.
      Title: In vitro osteoblast differentiation is negatively regulated by Hoxc8.
    8. Pcna is a direct downstream target of Hoxc8.
      Title: Proliferating cell nuclear antigen (Pcna) as a direct downstream target gene of Hoxc8.
    9. Our results provide evidence for a role for Hoxc8 in controlling cell cycle progression
      Title: Morpholino-mediated knockdown in primary chondrocytes implicates Hoxc8 in regulation of cell cycle progression.
    10. These results indicate that the 16 amino acid third helix is the key element responsible for the membrane transduction activity of Hoxc8 proteins.
      Title: The third helix of the murine Hoxc8 homeodomain facilitates protein transduction in mammalian cells.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein Hox-C8
    Names
    homeo box C8
    homeobox protein Hox-3.1
    homeobox protein M31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010466.2 → NP_034596.1  homeobox protein Hox-C8

      See identical proteins and their annotated locations for NP_034596.1

      Status: VALIDATED

      Source sequence(s)
      AC021667
      Consensus CDS
      CCDS27894.1
      UniProtKB/Swiss-Prot
      P09025
      Related
      ENSMUSP00000001703.7, ENSMUST00000001703.8
      Conserved Domains (1) summary
      pfam00046
      Location:153 → 206
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      102898971..102902707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248341.2 → XP_030104201.1  homeobox protein Hox-C8 isoform X1

      Conserved Domains (1) summary
      pfam00046
      Location:16 → 69
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09025.2 GenPept UniProtKB/Swiss-Prot:P09025

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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