Hoxb9 homeobox B9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxb9provided by MGI
Official Full Name: homeobox B9provided by MGI
Primary source: MGI:MGI:96190
See related: Ensembl:ENSMUSG00000020875 AllianceGenome:MGI:96190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hox-2.5
Summary: Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic skeletal system development; mammary gland development; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including early embryo; embryo mesenchyme; genitourinary system; gut; and nervous system. Orthologous to human HOXB9 (homeobox B9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 78.5), colon adult (RPKM 12.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.81 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96162156..96167421)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96271330..96276595)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WT1 regulates HOXB9 gene expression in a bidirectional way.
Title: WT1 regulates HOXB9 gene expression in a bidirectional way.
HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.
Title: HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.
Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites.
Title: Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites.
HOXB9 can suppress both phosphorylated-Akt expression and NF-kappaB activity. The latter phenomenon affects Snail protein expression and the inhibition of gastric carcinoma proliferation.
Title: HOXB9 inhibits proliferation in gastric carcinoma cells via suppression of phosphorylated-Akt and NF-κB-dependent Snail expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hoxb9 (e-PCR), detects polymorphism
- UniSTS:143385

Hoxb9 (e-PCR), detects polymorphism
- UniSTS:143386

Hoxb9 (e-PCR), detects polymorphism
- UniSTS:536656

Hoxb9 (e-PCR), detects polymorphism
- UniSTS:467539

NoName (e-PCR)
- UniSTS:489067

Hoxb9 (e-PCR), detects polymorphism
- UniSTS:536525

Clone Names

MGC124051, MGC124052, MGC124053, MGC124054

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal system morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mammary gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in proximal/distal pattern formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: homeobox protein Hox-B9

Names: homeo box B9; homeobox protein Hox-2.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.