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    Hmox2 heme oxygenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15369, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Hmox2provided by MGI
    Official Full Name
    heme oxygenase 2provided by MGI
    Primary source
    MGI:MGI:109373
    See related
    Ensembl:ENSMUSG00000004070 AllianceGenome:MGI:109373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HO2; HO-2
    Summary
    Predicted to enable heme binding activity and heme oxygenase (decyclizing) activity. Predicted to be involved in several processes, including iron ion homeostasis; porphyrin-containing compound catabolic process; and response to hypoxia. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human HMOX2 (heme oxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 136.2), cerebellum adult (RPKM 25.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A1; 16 2.46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4544225..4584606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4726361..4766742)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene STARR-seq mESC enhancer starr_39942 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4726231-4726340 Neighboring gene NmrA-like family domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_39943 Neighboring gene cell death inducing Trp53 target 1 Neighboring gene STARR-positive B cell enhancer ABC_E7425 Neighboring gene STARR-seq mESC enhancer starr_39945 Neighboring gene RIKEN cDNA 4930562C15 gene Neighboring gene predicted gene, 36513 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4878205-4878392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4879753-4879936 Neighboring gene UBA-like domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antithrombotic effects of heme-degrading and heme-binding proteins. Nath KA, et al. Am J Physiol Heart Circ Physiol, 2020 Mar 1. PMID 32004074, Free PMC Article
    2. Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex. Nath KA, et al. Am J Physiol Renal Physiol, 2019 Sep 1. PMID 31215802, Free PMC Article
    3. Heme oxygenase-2 suppresses acute inflammation and improves the survival of skin allografts. Chen R, et al. Int Immunopharmacol, 2018 Oct. PMID 30099287
    4. Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing. Bellner L, et al. FASEB J, 2015 Jan. PMID 25342128, Free PMC Article
    5. Heme oxygenase-2 suppress TNF-α and IL6 expression via TLR4/MyD88-dependent signaling pathway in mouse cerebral vascular endothelial cells. Chen RJ, et al. Mol Neurobiol, 2014 Dec. PMID 24788682

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice.
      Title: Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice.
    2. Altered Expression of Heme Oxygenase 2 in Heme Oxygenase 1-deficient Mouse Embryos.
      Title: Altered Expression of Heme Oxygenase 2 in Heme Oxygenase 1-deficient Mouse Embryos.
    3. Heme Oxygenase 1 and 2 Differentially Regulate Glucose Metabolism and Adipose Tissue Mitochondrial Respiration: Implications for Metabolic Dysregulation.
      Title: Heme Oxygenase 1 and 2 Differentially Regulate Glucose Metabolism and Adipose Tissue Mitochondrial Respiration: Implications for Metabolic Dysregulation.
    4. Aged male mice are hypersensitive to ischemic acute kidney injury and HO-2 mitigates such sensitivity. This protective effect of HO-2 may be mediated, at least in part, by suppression of phosphorylated STAT3-dependent signaling.
      Title: Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex.
    5. This study demonstrated that HO-2 is involved in reducing inflammatory responses mediated by macrophages. Downstream factors (TNF-alpha, IL1beta and IL-6) that play a role in the TLR4 signaling pathway were suppressed in HO-2 overexpressing macrophages. HO-2 enhanced the survival of allografted skin.
      Title: Heme oxygenase-2 suppresses acute inflammation and improves the survival of skin allografts.
    6. This study demonstrated that Deletion of the heme oxygenase-2 aggravates brain injury following stroma-free hemoglobin-induced
      Title: Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.
    7. Data indicate that injury induced heme oxygenase 1 (HO-1) expression in both heme oxygenase 2 (HO-2) knockout and wild type mice.
      Title: Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression.
    8. HO-2 shRNA and HO-2 overexpression plasmids were used to observe the effect of HO-2 in cerebral microvascular endothelial cells. mRNA and protein levels of TNF-alpha and IL6 were increased and decreased, respectively, compared with control groups.
      Title: Heme oxygenase-2 suppress TNF-α and IL6 expression via TLR4/MyD88-dependent signaling pathway in mouse cerebral vascular endothelial cells.
    9. macrophage HO-2 is required for proper macrophage function but is insufficient to correct the impaired healing of the HO-2(-/-) cornea, suggesting that corneal epithelial expression of HO-2 is a key to resolution and repair in wound healing
      Title: Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing.
    10. These results demonstrate a sex-specific effect of HO-2 deficiency on the development of renovascular hypertension and its effects on the heart in response to the increase in blood pressure.
      Title: Sex-specific effects of heme oxygenase-2 deficiency on renovascular hypertension.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme oxygenase (decyclizing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme oxygenase (decyclizing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heme oxygenase 2
    Names
    heme oxygenase (decycling) 2
    NP_001129538.1
    NP_001343979.1
    NP_001365928.1
    NP_034573.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136066.2 → NP_001129538.1  heme oxygenase 2 isoform 1

      See identical proteins and their annotated locations for NP_001129538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK134536, BP769523, BY071995
      Consensus CDS
      CCDS27924.1
      UniProtKB/Swiss-Prot
      O70252, O70626
      UniProtKB/TrEMBL
      Q3U6W4, Q544R7
      Related
      ENSMUSP00000004172.9, ENSMUST00000004172.15
      Conserved Domains (1) summary
      pfam01126
      Location:30 → 235
      Heme_oxygenase; Heme oxygenase

    2. NM_001357050.1 → NP_001343979.1  heme oxygenase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166903
      UniProtKB/TrEMBL
      Q3U6W4
      Conserved Domains (1) summary
      pfam01126
      Location:58 → 263
      Heme_oxygenase; Heme oxygenase

    3. NM_001378999.1 → NP_001365928.1  heme oxygenase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166903
      UniProtKB/TrEMBL
      Q3U6W4
      Conserved Domains (1) summary
      pfam01126
      Location:49 → 254
      Heme_oxygenase; Heme oxygenase

    4. NM_010443.2 → NP_034573.2  heme oxygenase 2 isoform 1

      See identical proteins and their annotated locations for NP_034573.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to transcript variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK134536, BP769523, CA465845
      Consensus CDS
      CCDS27924.1
      UniProtKB/Swiss-Prot
      O70252, O70626
      UniProtKB/TrEMBL
      Q3U6W4, Q544R7
      Related
      ENSMUSP00000112397.2, ENSMUST00000120232.8
      Conserved Domains (1) summary
      pfam01126
      Location:30 → 235
      Heme_oxygenase; Heme oxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4544225..4584606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70252.1 GenPept UniProtKB/Swiss-Prot:O70252

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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