U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Hmmr hyaluronan mediated motility receptor (RHAMM) [ Mus musculus (house mouse) ]

    Gene ID: 15366, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hmmrprovided by MGI
    Official Full Name
    hyaluronan mediated motility receptor (RHAMM)provided by MGI
    Primary source
    MGI:MGI:104667
    See related
    Ensembl:ENSMUSG00000020330 AllianceGenome:MGI:104667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD168; Rhamm; AA386826
    Summary
    Predicted to enable hyaluronic acid binding activity. Predicted to be located in centrosome and cytosol. Is expressed in bulbar cushion and testis. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human HMMR (hyaluronan mediated motility receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 13.5), liver E14.5 (RPKM 10.2) and 10 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 A5; 11 24.4 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (40592215..40624290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (40701388..40733464, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene methionine adenosyltransferase 2 non-catalytic beta subunit methionine Neighboring gene STARR-positive B cell enhancer ABC_E6966 Neighboring gene STARR-seq mESC enhancer starr_29231 Neighboring gene STARR-seq mESC enhancer starr_29232 Neighboring gene NudC domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_29234 Neighboring gene cyclin G1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization. Tolg C, et al. J Biol Chem, 2020 Apr 17. PMID 32165498, Free PMC Article
    2. The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury. Cui Z, et al. Matrix Biol, 2019 May. PMID 30098420, Free PMC Article
    3. RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility. Li H, et al. Biol Open, 2015 Mar 6. PMID 25750434, Free PMC Article
    4. The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells. Jiang J, et al. PLoS One, 2013. PMID 24019927, Free PMC Article
    5. A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds. Tolg C, et al. Am J Pathol, 2012 Oct. PMID 22889846, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-cell transcriptomic analysis identifies a highly replicating Cd168[+] skeletal stem/progenitor cell population in mouse long bones.
      Title: Single-cell transcriptomic analysis identifies a highly replicating Cd168(+) skeletal stem/progenitor cell population in mouse long bones.
    2. HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
      Title: HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
    3. Oleate acid-stimulated HMMR expression by CEBPalpha is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma.
      Title: Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma.
    4. High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate the progression of pancreatic cancer.
      Title: High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate the progression of pancreatic cancer.
    5. Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization.
      Title: Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization.
    6. Study provides evidence that RHAMM is a critical component of the inflammatory response, respiratory distress and fibrosis after acute lung injury.
      Title: The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury.
    7. Results showed, for the first time, the distribution and activity of RHAMM in the context of skeletal muscle, and established that CD44 and RHAMM activation promote myogenic and connective tissue migration and proliferation.
      Title: Hyaluronic acid, CD44 and RHAMM regulate myoblast behavior during embryogenesis.
    8. These data identify an essential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division and supports neural development.
      Title: HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
    9. RHAMM localises at the mitotic spindle of ovarian granulosa cells via its C-terminus, deletion of which impairs proper spindle orientation and folliculogenesis.
      Title: RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility.
    10. RHAMM is not found on the cell-surface of embryonic stem cells, but it is required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules
      Title: The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyaluronan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hyaluronan catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    hyaluronan mediated motility receptor
    Names
    intracellular hyaluronic acid-binding protein
    receptor for hyaluronan-mediated motility

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013552.2 → NP_038580.2  hyaluronan mediated motility receptor

      See identical proteins and their annotated locations for NP_038580.2

      Status: VALIDATED

      Source sequence(s)
      AF031932, AK143123, AL646055, CN455388
      Consensus CDS
      CCDS24548.1
      UniProtKB/Swiss-Prot
      Q00547, Q5NC88
      UniProtKB/TrEMBL
      Q8VDR2
      Related
      ENSMUSP00000020579.8, ENSMUST00000020579.9
      Conserved Domains (3) summary
      pfam15905
      Location:16 → 338
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      pfam15908
      Location:636 → 789
      HMMR_C; Hyaluronan mediated motility receptor C-terminal
      cl19219
      Location:277 → 431
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      40592215..40624290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156344.1 → XP_036012237.1  hyaluronan mediated motility receptor isoform X1

      UniProtKB/TrEMBL
      Q8VDR2
      Conserved Domains (3) summary
      PRK02224
      Location:104 → 575
      PRK02224; DNA double-strand break repair Rad50 ATPase
      pfam15905
      Location:16 → 337
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      pfam15908
      Location:635 → 788
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    2. XM_006532279.4 → XP_006532342.1  hyaluronan mediated motility receptor isoform X4

      Conserved Domains (3) summary
      PRK02224
      Location:38 → 541
      PRK02224; DNA double-strand break repair Rad50 ATPase
      pfam15905
      Location:1 → 154
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      pfam15908
      Location:431 → 584
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    3. XM_006532278.4 → XP_006532341.1  hyaluronan mediated motility receptor isoform X3

      Conserved Domains (3) summary
      TIGR02168
      Location:191 → 472
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15905
      Location:1 → 154
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      pfam15908
      Location:452 → 605
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    4. XM_006532276.5 → XP_006532339.1  hyaluronan mediated motility receptor isoform X2

      UniProtKB/TrEMBL
      Q8VDR2
      Conserved Domains (3) summary
      PRK02224
      Location:222 → 731
      PRK02224; DNA double-strand break repair Rad50 ATPase
      pfam15905
      Location:16 → 338
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      pfam15908
      Location:615 → 768
      HMMR_C; Hyaluronan mediated motility receptor C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00547.4 GenPept UniProtKB/Swiss-Prot:Q00547

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous