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    Hic1 hypermethylated in cancer 1 [ Mus musculus (house mouse) ]

    Gene ID: 15248, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Hic1provided by MGI
    Official Full Name
    hypermethylated in cancer 1provided by MGI
    Primary source
    MGI:MGI:1338010
    See related
    Ensembl:ENSMUSG00000043099 AllianceGenome:MGI:1338010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HIC-1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 27.9), limb E14.5 (RPKM 25.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 45.76 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75052203..75059970, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75161377..75170255, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SMG6 nonsense mediated mRNA decay factor Neighboring gene ribosomal protein S12, pseudogene 19 Neighboring gene predicted gene, 51907 Neighboring gene RIKEN cDNA 1700016P03 gene Neighboring gene STARR-positive B cell enhancer ABC_E10686 Neighboring gene microRNA 212 Neighboring gene microRNA 132

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis. Burrows K, et al. PLoS Pathog, 2018 Feb. PMID 29470558, Free PMC Article
    2. The transcriptional repressor HIC1 regulates intestinal immune homeostasis. Burrows K, et al. Mucosal Immunol, 2017 Nov. PMID 28327618
    3. Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Pospichalova V, et al. Genesis, 2011 Mar. PMID 21309068
    4. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Chen WY, et al. Nat Genet, 2003 Feb. PMID 12539045
    5. Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Carter MG, et al. Hum Mol Genet, 2000 Feb 12. PMID 10655551

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.
      Title: HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.
    2. Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
      Title: Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
    3. Loss of HIC1 in KrasG12D/+(Lox-Stop-Lox)/sgHIC1 mice could promote tumorigenesis.
      Title: Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression.
    4. Loss of Hic1 expression in the early stages of tumor formation may contribute to malignant transformation through the acquisition of chromosomal instability.
      Title: The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
    5. Intestinal innate lymphoid cells express HIC1 in a vitamin A-dependent manner.
      Title: HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.
    6. this study identified a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions
      Title: The transcriptional repressor HIC1 regulates intestinal immune homeostasis.
    7. HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
      Title: HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
    8. identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb-like proteins.
      Title: Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins.
    9. Data show that Hic1 expression is absent in polyps from DH mice, with concomitant increased expression of two transcriptional repression targets of Hic1, Sirt1 and Sox9.
      Title: Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
    10. A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
      Title: A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hypermethylated in cancer 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098203.1 → NP_001091673.1  hypermethylated in cancer 1 protein isoform 2

      See identical proteins and their annotated locations for NP_001091673.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL603905, BU757195, CJ126522
      UniProtKB/Swiss-Prot
      B1ARH0, Q9R1Y5, Q9R1Y6, Q9R2B0
      Related
      ENSMUSP00001091661.1, ENSMUST00000131720.3
      Conserved Domains (6) summary
      smart00225
      Location:48 → 152
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:561 → 609
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:537 → 557
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:535 → 557
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:37 → 150
      BTB; BTB/POZ domain
      pfam13465
      Location:578 → 602
      zf-H2C2_2; Zinc-finger double domain

    2. NM_010430.3 → NP_034560.3  hypermethylated in cancer 1 protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL603905
      Consensus CDS
      CCDS36226.1
      UniProtKB/TrEMBL
      Z4YJP0
      Related
      ENSMUSP00000053483.6, ENSMUST00000055619.6
      Conserved Domains (5) summary
      COG5048
      Location:482 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18333
      Location:7 → 136
      BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)
      pfam00096
      Location:516 → 538
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75052203..75059970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532275.3 → XP_006532338.1  hypermethylated in cancer 1 protein isoform X1

      UniProtKB/TrEMBL
      Z4YJP0
      Conserved Domains (5) summary
      COG5048
      Location:482 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18333
      Location:7 → 136
      BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)
      pfam00096
      Location:516 → 538
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1Y5.4 GenPept UniProtKB/Swiss-Prot:Q9R1Y5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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