Mst1 macrophage stimulating 1 (hepatocyte growth factor-like) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mst1provided by MGI
Official Full Name: macrophage stimulating 1 (hepatocyte growth factor-like)provided by MGI
Primary source: MGI:MGI:96080
See related: Ensembl:ENSMUSG00000032591 AllianceGenome:MGI:96080
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hgfl; D3F15S2h; DNF15S2h; D9H3F15S2
Summary: Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including embryo implantation; mammary duct terminal end bud growth; and positive regulation of mammary gland epithelial cell proliferation. Located in vacuole. Is expressed in esophagus epithelium; liver; liver parenchyma; pharynx epithelium; and stomach proventricular region epithelium. Orthologous to several human genes including MST1 (macrophage stimulating 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 91.5), liver E18 (RPKM 53.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 59.07 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107957607..107962226)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108080409..108085027)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3beta/beta-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
Title: Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
Title: CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.
Title: Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.
Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.
Title: Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.
Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.
Title: Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.
WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.
Title: WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.
Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.
Title: Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.
Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.
Title: Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.
Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.
Title: Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.
this study confirms that melatonin rescues the impaired mitophagy activity of diabetic cardiomyopathy . The underlying mechanism may be attributed to activation of Parkin translocation via inhibition of Mst
Title: Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone kinase activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo implantation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mammary duct terminal end bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hepatocyte growth factor-like protein

Names: MSP; macrophage stimulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008243.3 → NP_032269.3 hepatocyte growth factor-like protein precursor

See identical proteins and their annotated locations for NP_032269.3

Status: VALIDATED

Source sequence(s)

AC137678, AK134222, M74181

Consensus CDS

CCDS40766.1

UniProtKB/Swiss-Prot

P26928, Q6GTL1

UniProtKB/TrEMBL

Q3UZ05

Related

ENSMUSP00000035211.8, ENSMUST00000035211.14

Conserved Domains (4) summary

smart00020
Location:488 → 709

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:377 → 459

KR; Kringle domain

cd00190
Location:489 → 712

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00024
Location:25 → 96

PAN_1; PAN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107957607..107962226

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511639.5 → XP_006511702.2 hepatocyte growth factor-like protein isoform X1

Conserved Domains (3) summary

smart00130
Location:400 → 482

KR; Kringle domain

pfam00051
Location:191 → 268

Kringle; Kringle domain

pfam00024
Location:25 → 96

PAN_1; PAN domain
XM_011242856.4 → XP_011241158.1 hepatocyte growth factor-like protein isoform X2

Conserved Domains (1) summary

cd00190
Location:231 → 454

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_030244059.1 → XP_030099919.1 hepatocyte growth factor-like protein isoform X3

Conserved Domains (3) summary

smart00130
Location:46 → 128

KR; Kringle domain

cd00190
Location:158 → 381

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl00100
Location:4 → 39

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
XM_030244060.1 → XP_030099920.1 hepatocyte growth factor-like protein isoform X4

Conserved Domains (1) summary

cd00190
Location:143 → 366

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...