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    H2-DMb2 histocompatibility 2, class II, locus Mb2 [ Mus musculus (house mouse) ]

    Gene ID: 15000, updated on 5-Mar-2024

    Summary

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    Official Symbol
    H2-DMb2provided by MGI
    Official Full Name
    histocompatibility 2, class II, locus Mb2provided by MGI
    Primary source
    MGI:MGI:95923
    See related
    Ensembl:ENSMUSG00000037548 AllianceGenome:MGI:95923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-2Mb2; H2-Mb2
    Summary
    Predicted to enable MHC class II protein complex binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and chaperone cofactor-dependent protein refolding. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is integral component of membrane. Orthologous to human HLA-DMB (major histocompatibility complex, class II, DM beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 391.6), mammary gland adult (RPKM 128.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34362203..34370527)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34143229..34151553)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC051537 Neighboring gene STARR-positive B cell enhancer ABC_E11637 Neighboring gene histocompatibility 2, O region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E7522 Neighboring gene STARR-seq mESC enhancer starr_42423 Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34266262-34266415 Neighboring gene STARR-positive B cell enhancer ABC_E117 Neighboring gene STARR-positive B cell enhancer ABC_E1503 Neighboring gene STARR-positive B cell enhancer ABC_E1504 Neighboring gene STARR-positive B cell enhancer ABC_E7523 Neighboring gene histocompatibility 2, class II, locus Mb1 Neighboring gene STARR-positive B cell enhancer ABC_E11638 Neighboring gene STARR-positive B cell enhancer ABC_E1939 Neighboring gene STARR-seq mESC enhancer starr_42425 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of mouse H2-M. Fremont DH, et al. Immunity, 1998 Sep. PMID 9768758
    2. Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development. Georgiades P, et al. Immunology, 1996 Jul. PMID 8774363, Free PMC Article
    3. H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove. Walter W, et al. Immunogenetics, 1996. PMID 8613139
    4. Characterization of polymorphism within the H2-M MHC class II loci. Hermel E, et al. Immunogenetics, 1995. PMID 7607704
    5. New class II-like genes in the murine MHC. Cho SG, et al. Nature, 1991 Oct 10. PMID 1922366

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class II protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MHC class II protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within antigen processing and presentation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide antigen assembly with MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histocompatibility 2, class II, locus Mb2
    Names
    H2-M beta2
    MHC class II antigen Mb2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010388.5 → NP_034518.1  histocompatibility 2, class II, locus Mb2 precursor

      See identical proteins and their annotated locations for NP_034518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      CR974422
      Consensus CDS
      CCDS37580.1
      UniProtKB/TrEMBL
      Q31099, Q31609, Q60975, Q95552
      Related
      ENSMUSP00000043526.8, ENSMUST00000041982.9
      Conserved Domains (3) summary
      smart00410
      Location:129 → 201
      IG_like; Immunoglobulin like
      pfam00969
      Location:27 → 106
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      cl11960
      Location:115 → 209
      Ig; Immunoglobulin domain

    RNA

    1. NR_160895.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974422
      Related
      ENSMUST00000171231.8

    2. NR_160896.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974422
      Related
      ENSMUST00000236519.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34362203..34370527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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