H2-M3 histocompatibility 2, M region locus 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-M3provided by MGI
Official Full Name: histocompatibility 2, M region locus 3provided by MGI
Primary source: MGI:MGI:95915
See related: Ensembl:ENSMUSG00000016206 AllianceGenome:MGI:95915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hmt; M3a; R4B2; H-2M3; MuprM3; MuprM301; MuprM302
Summary: Enables peptide antigen binding activity. Acts upstream of or within several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; positive regulation of leukocyte mediated cytotoxicity; and response to bacterium. Located in external side of plasma membrane. Part of MHC class Ib protein complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 13.5), mammary gland adult (RPKM 8.7) and 20 other tissues See more
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Genomic context

Location:: 17 B1; 17 19.16 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (37581094..37585380)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (37270234..37274485)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study found the receptor Ly49A bound the MHC class I molecule H2-M3 with an affinity similar to its affinity for H-2D(d); specific recognition of H2-M3 by Ly49A regulated 'licensing' of NK cells and mediated 'missing-self' recognition of H2-M3-deficient bone marrow
Title: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.
Similar to H2-M3-restricted CD8-positive T cells, CD8+ T cells restricted to other major histocompatibility class Ib molecules are able to undergo extensive proliferation after primary infection with Listeria monocytogenes.
Title: Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3.
H2-M3-restricted CD8+ T cells contribute to protective immunity against intracellular bacterial pathogen Chlamydia pneumoniae.
Title: CD8+ T cell protective immunity against Chlamydia pneumoniae includes an H2-M3-restricted response that is largely CD4+ T cell-independent.
Activation and proliferation of M3-restricted CD8+ T cells is not required for protective immunity against Listeria monocytogenes
Title: H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes.
MHC class Ia-restricted responses cannot compensate for H2-M3-mediated immunity; a nonredundant role of H2-M3 is suggested in protective immunity against Listeria monocytogenes.
Title: Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense.
The association of H2-M3 molecules with the peptide-loading complex of the endoplasmic reticulum is dramatically decreased by incubation of live cells with exogenous M3 ligands.
Title: Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

U18797 (e-PCR)
- UniSTS:160658

H2-M3 (e-PCR), detects polymorphism
- UniSTS:525229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD8 receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide antigen binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within alpha-beta T cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class Ib	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class Ib protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histocompatibility 2, M region locus 3

Names: MHC class I-b antigen M3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013819.3 → NP_038847.1 histocompatibility 2, M region locus 3 precursor

See identical proteins and their annotated locations for NP_038847.1

Status: VALIDATED

Source sequence(s)

CT033782

Consensus CDS

CCDS37617.1

UniProtKB/TrEMBL

Q31093, Q8MHM0

Related

ENSMUSP00000035687.7, ENSMUST00000038580.7

Conserved Domains (2) summary

cd07698
Location:207 → 298

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:25 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

37581094..37585380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160327.1 → XP_036016220.1 histocompatibility 2, M region locus 3 isoform X1

UniProtKB/TrEMBL

Q8MHM0

Conserved Domains (2) summary

pfam00129
Location:25 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cd07698
Location:207 → 298

IgC1_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain, alpha3 immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains