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    Gstm6 glutathione S-transferase, mu 6 [ Mus musculus (house mouse) ]

    Gene ID: 14867, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Gstm6provided by MGI
    Official Full Name
    glutathione S-transferase, mu 6provided by MGI
    Primary source
    MGI:MGI:1309467
    See related
    Ensembl:ENSMUSG00000068762 AllianceGenome:MGI:1309467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and protein homodimerization activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytosol and intercellular bridge. Is expressed in several structures, including genitourinary system; heart; intestine; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 42.7), genital fat pad adult (RPKM 32.0) and 7 other tissues See more
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    Genomic context

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    Location:
    3 F2.3; 3 46.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107846163..107860957, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107938847..107953641, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9515 Neighboring gene glutathione S-transferase, mu 7 Neighboring gene glutathione S-transferase, mu 3 Neighboring gene predicted pseudogene 12497

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel murine glutathione S-transferase class mu gene. De Bruin WC, et al. Biochem J, 1998 Mar 1. PMID 9480867, Free PMC Article
    2. Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice. Beverdam A, et al. Reproduction, 2009 Mar. PMID 19098141
    3. Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Lee FY, et al. Dev Cell, 2011 Aug 16. PMID 21820362, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase Mu 6
    Names
    GST class-mu 6
    glutathione-S-transferase class M5
    NP_001366433.1
    NP_001366434.1
    NP_001366435.1
    NP_001366436.1
    NP_001366437.1
    NP_001366438.1
    NP_001366439.1
    NP_032210.3
    XP_006501086.1
    XP_006501088.1
    XP_030108293.1
    XP_036018796.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379504.1 → NP_001366433.1  glutathione S-transferase Mu 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079042
      UniProtKB/TrEMBL
      Q9D5J8
      Conserved Domains (3) summary
      cd03209
      Location:127 → 247
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:48 → 119
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:10 → 47
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001379505.1 → NP_001366434.1  glutathione S-transferase Mu 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079042
      UniProtKB/TrEMBL
      Q9D5J8
      Conserved Domains (2) summary
      cd03209
      Location:106 → 226
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:19 → 98
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    3. NM_001379506.1 → NP_001366435.1  glutathione S-transferase Mu 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC079042
      UniProtKB/TrEMBL
      G5E8M7, Q9D5J8
      Related
      ENSMUSP00000102295.2, ENSMUST00000106684.8
      Conserved Domains (2) summary
      cd03209
      Location:92 → 226
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    4. NM_001379507.1 → NP_001366436.1  glutathione S-transferase Mu 6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC079042
      UniProtKB/TrEMBL
      Q9D5J8
      Conserved Domains (2) summary
      cd03209
      Location:90 → 210
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:11 → 82
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    5. NM_001379508.1 → NP_001366437.1  glutathione S-transferase Mu 6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079042
      UniProtKB/TrEMBL
      D3YVP9
      Related
      ENSMUSP00000102292.2, ENSMUST00000106681.3
      Conserved Domains (2) summary
      cd03209
      Location:58 → 178
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:1 → 50
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    6. NM_001379509.1 → NP_001366438.1  glutathione S-transferase Mu 6 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC079042
      Conserved Domains (2) summary
      cl00388
      Location:3 → 59
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:60 → 151
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    7. NM_001379510.1 → NP_001366439.1  glutathione S-transferase Mu 6 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC079042
      UniProtKB/TrEMBL
      D3YVP8
      Related
      ENSMUSP00000102294.2, ENSMUST00000106683.8
      Conserved Domains (2) summary
      cl00388
      Location:1 → 25
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:26 → 117
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    8. NM_008184.4 → NP_032210.3  glutathione S-transferase Mu 6 isoform 4

      See identical proteins and their annotated locations for NP_032210.3

      Status: VALIDATED

      Source sequence(s)
      AC079042
      Consensus CDS
      CCDS38596.1
      UniProtKB/Swiss-Prot
      O35660, O35661, Q8K0C3
      UniProtKB/TrEMBL
      Q9D5J8
      Related
      ENSMUSP00000102296.3, ENSMUST00000106685.9
      Conserved Domains (3) summary
      PTZ00057
      Location:3 → 202
      PTZ00057; glutathione s-transferase; Provisional
      cd03209
      Location:92 → 212
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107846163..107860957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162903.1 → XP_036018796.1  glutathione S-transferase Mu 6 isoform X3

      Conserved Domains (2) summary
      cl00388
      Location:11 → 57
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:58 → 149
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_006501025.4 → XP_006501088.1  glutathione S-transferase Mu 6 isoform X2

      Conserved Domains (2) summary
      cl00388
      Location:48 → 94
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:95 → 186
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    3. XM_006501023.1 → XP_006501086.1  glutathione S-transferase Mu 6 isoform X1

      UniProtKB/TrEMBL
      Q9D5J8
      Conserved Domains (3) summary
      cd03209
      Location:101 → 221
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:22 → 93
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:1 → 21
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    4. XM_030252433.1 → XP_030108293.1  glutathione S-transferase Mu 6 isoform X4

      Conserved Domains (2) summary
      cd03075
      Location:48 → 119
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:10 → 47
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35660.4 GenPept UniProtKB/Swiss-Prot:O35660

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