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    Gstm4 glutathione S-transferase, mu 4 [ Mus musculus (house mouse) ]

    Gene ID: 14865, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Gstm4provided by MGI
    Official Full Name
    glutathione S-transferase, mu 4provided by MGI
    Primary source
    MGI:MGI:95862
    See related
    Ensembl:ENSMUSG00000027890 AllianceGenome:MGI:95862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gstb4; Gstb-4; GSTM4-4; GSTM7-7; 1110004G14Rik
    Summary
    Enables glutathione transferase activity. Acts upstream of or within nitrobenzene metabolic process and xenobiotic catabolic process. Predicted to be located in cytosol and intercellular bridge. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to human GSTM4 (glutathione S-transferase mu 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 39.1), liver adult (RPKM 27.9) and 27 other tissues See more
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    Genomic context

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    See Gstm4 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.83 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107937887..107952495, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108030571..108045179, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107820964-107821073 Neighboring gene glutathione S-transferase, mu 1 Neighboring gene predicted gene 12502 Neighboring gene predicted gene, 36498 Neighboring gene predicted gene, 25592 Neighboring gene STARR-seq mESC enhancer starr_08678 Neighboring gene adenosine monophosphate deaminase 2 Neighboring gene predicted gene 12500 Neighboring gene G protein subunit alpha transducin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Chanas SA, et al. Biochem J, 2002 Jul 15. PMID 11991805, Free PMC Article
    2. Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme. Guo J, et al. Biochem J, 2002 Sep 15. PMID 12069689, Free PMC Article
    3. The structure of two murine class-mu glutathione transferase genes coordinately induced by butylated hydroxyanisole. Reinhart J, et al. Arch Biochem Biophys, 1993 Jun. PMID 8512323
    4. Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size. Yuan R, et al. Aging Cell, 2006 Jun. PMID 16842493
    5. Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution. Norrgård MA, et al. Proc Natl Acad Sci U S A, 2006 Mar 28. PMID 16549767, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40906

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nitrobenzene metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase Mu 4
    Names
    GST class-mu 4
    glutathione transferase GSTM7-7
    leukotriene C4 synthase GSTM4
    NP_001153883.1
    NP_081040.1
    XP_006501081.1
    XP_006501083.1
    XP_006501084.1
    XP_017174951.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160411.2 → NP_001153883.1  glutathione S-transferase Mu 4 isoform 2

      See identical proteins and their annotated locations for NP_001153883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL671877
      Consensus CDS
      CCDS51045.1
      UniProtKB/TrEMBL
      A2AE91
      Related
      ENSMUSP00000136643.2, ENSMUST00000178808.8
      Conserved Domains (2) summary
      cd03209
      Location:58 → 177
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:1 → 50
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_001428456.1 → NP_001415385.1  glutathione S-transferase Mu 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671877
      UniProtKB/TrEMBL
      A2AE91

    3. NM_001428457.1 → NP_001415386.1  glutathione S-transferase Mu 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671877
      UniProtKB/TrEMBL
      A2AE91

    4. NM_001428458.1 → NP_001415387.1  glutathione S-transferase Mu 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671877
      UniProtKB/TrEMBL
      A2AE91

    5. NM_026764.4 → NP_081040.1  glutathione S-transferase Mu 4 isoform 1

      See identical proteins and their annotated locations for NP_081040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL671877
      Consensus CDS
      CCDS17748.1
      UniProtKB/Swiss-Prot
      Q8R5I6
      Related
      ENSMUSP00000029489.9, ENSMUST00000029489.15
      Conserved Domains (2) summary
      cd03209
      Location:92 → 211
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107937887..107952495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319462.3 → XP_017174951.1  glutathione S-transferase Mu 4 isoform X2

      Conserved Domains (2) summary
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:92 → 120
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_006501020.4 → XP_006501083.1  glutathione S-transferase Mu 4 isoform X1

      Conserved Domains (2) summary
      cd03209
      Location:58 → 177
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:1 → 50
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. XM_006501021.4 → XP_006501084.1  glutathione S-transferase Mu 4 isoform X1

      Conserved Domains (2) summary
      cd03209
      Location:58 → 177
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:1 → 50
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    4. XM_006501018.2 → XP_006501081.1  glutathione S-transferase Mu 4 isoform X1

      Related
      ENSMUSP00000102281.2, ENSMUST00000106670.2
      Conserved Domains (2) summary
      cd03209
      Location:58 → 177
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:1 → 50
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5I6.1 GenPept UniProtKB/Swiss-Prot:Q8R5I6

    Gene LinkOut

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