U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Gspt2 G1 to S phase transition 2 [ Mus musculus (house mouse) ]

    Gene ID: 14853, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gspt2provided by MGI
    Official Full Name
    G1 to S phase transition 2provided by MGI
    Primary source
    MGI:MGI:1316727
    See related
    Ensembl:ENSMUSG00000071723 AllianceGenome:MGI:1316727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in cytoplasmic translational termination. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in adrenal gland; genitourinary system; intestine; and spinal cord. Orthologous to human GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    X C3; X 41.63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93679675..93682168)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94636069..94638562)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5401 Neighboring gene predicted pseudogene 9009 Neighboring gene STARR-seq mESC enhancer starr_47561 Neighboring gene STARR-seq mESC enhancer starr_47562 Neighboring gene SUMO/sentrin specific peptidase pseudogene Neighboring gene zinc finger, X-linked, duplicated B

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. Hoshino S, et al. J Biol Chem, 1998 Aug 28. PMID 9712840
    2. Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton. Li X, et al. Mol Cell, 2014 Jul 17. PMID 24981173, Free PMC Article
    3. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article
    4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC143748, MGC143749

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation release factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    eukaryotic peptide chain release factor GTP-binding subunit ERF3B
    Names
    G1 to S phase transition protein 2 homolog
    eRF3b
    eukaryotic peptide chain release factor subunit 3b

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008179.2 → NP_032205.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3B

      See identical proteins and their annotated locations for NP_032205.2

      Status: VALIDATED

      Source sequence(s)
      AL645466, AW125523
      Consensus CDS
      CCDS41064.1
      UniProtKB/Swiss-Prot
      O88180, Q149F3, Q9CY91
      Related
      ENSMUSP00000109523.2, ENSMUST00000096368.4
      Conserved Domains (5) summary
      cd01883
      Location:209 → 425
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:205 → 629
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:54 → 71
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:434 → 514
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:521 → 627
      eRF3_C_III; C-terminal domain of eRF3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93679675..93682168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q149F3.1 GenPept UniProtKB/Swiss-Prot:Q149F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous