Pdia3 protein disulfide isomerase associated 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdia3provided by MGI
Official Full Name: protein disulfide isomerase associated 3provided by MGI
Primary source: MGI:MGI:95834
See related: Ensembl:ENSMUSG00000027248 AllianceGenome:MGI:95834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Erp; PDI; Plca; 58kDa; ERp57; ERp60; ERp61; Grp58; PDI-Q2; PI-PLC; PLC[a]
Summary: Predicted to enable several functions, including identical protein binding activity; protein disulfide isomerase activity; and protein-disulfide reductase (glutathione) activity. Acts upstream of or within cellular response to interleukin-7 and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 203.6), ovary adult (RPKM 132.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.38 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (121244383..121269168)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (121413902..121438687)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
Title: A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes.
Title: PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes.
Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.
Title: Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.
Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung.
Title: Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung.
ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation.
Title: ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation.
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS.
Title: Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS.
The role of PDIA3 in myogenesis during muscle regeneration.
Title: The role of PDIA3 in myogenesis during muscle regeneration.
Protein disulfide isomerase associated 3 (PDIA3) knockout PDIA(-/-) provided significant improvements in cognitive impairments and contusion volume induced by traumatic brain injury (TBI).
Title: PDIA3-regulted inflammation and oxidative stress contribute to the traumatic brain injury (TBI) in mice.
data reveal that the loss of the protein disulfide isomerase ERp57 is sufficient to induce ER stress in chondrocytes.
Title: 4-Phenylbutyric Acid Reduces Endoplasmic Reticulum Stress in Chondrocytes That Is Caused by Loss of the Protein Disulfide Isomerase ERp57.
these results indicate that PDIA3 is required for effective influenza pathogenesis in vivo, and pharmacological inhibition of PDIs represents a promising new anti-influenza therapeutic strategy during pandemic and severe influenza seasons.
Title: Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC299835P1 (e-PCR)
- UniSTS:272466

Pdia3 (e-PCR), detects polymorphism
- UniSTS:470674

Grp58 (e-PCR), detects polymorphism
- UniSTS:143007

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase (glutathione) activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-7	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vitamin D	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen assembly with MHC class I protein complex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class I peptide loading complex	ISO Inferred from Sequence Orthology more info
part_of TAP complex	ISO Inferred from Sequence Orthology more info
part_of Tapasin-ERp57 complex	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein disulfide-isomerase A3

Names: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; ER protein 57; ER protein 60; disulfide isomerase ER-60; endoplasmic reticulum protein; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; glucose regulated protein, 58 kDa; p58; phospholipase C, alpha

NP_031978.2

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007952.2 → NP_031978.2 protein disulfide-isomerase A3 precursor

See identical proteins and their annotated locations for NP_031978.2

Status: VALIDATED

Source sequence(s)

AK132459, AK133799, AL845466, BQ033063, BQ714617

Consensus CDS

CCDS16643.1

UniProtKB/Swiss-Prot

P27773, Q3TEI9, Q3TIL2, Q3UZK8, Q8C2F4, Q99LF6

Related

ENSMUSP00000028683.8, ENSMUST00000028683.14

Conserved Domains (5) summary

cd02995
Location:377 → 480

PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...

cd03069
Location:135 → 240

PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...

cd03073
Location:244 → 357

PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...

TIGR01130
Location:26 → 487

ER_PDI_fam; protein disulfide isomerase, eukaryotic

pfam00085
Location:27 → 131

Thioredoxin; Thioredoxin