Gsr glutathione reductase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsrprovided by MGI
Official Full Name: glutathione reductaseprovided by MGI
Primary source: MGI:MGI:95804
See related: Ensembl:ENSMUSG00000031584 AllianceGenome:MGI:95804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gr1; Gr-1; D8Ertd238e
Summary: Enables glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in several processes, including cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Located in external side of plasma membrane. Is expressed in brain ventricular layer; gut; lung; metanephros; and retina. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 47.5), kidney adult (RPKM 30.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 20.69 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (34143266..34188190)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (33653238..33698162)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice?
Title: How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice?
The results suggest that Nanog represses Gsr gene expression in embryonic stem cells, evidencing a role of this crucial pluripotency transcription factor in preservation of redox homeostasis in stem cells.
Title: The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells.
This study identifies glutathione reductase as an effective regulator of oxidative stress that affects the multistep processes of metastasis in melanoma cells, and it becomes a potential target for melanoma therapy.
Title: Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells.
GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin reductase system can probably operate as a functional backup for GSR.
Title: GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR.
Data show that reducing RGS2 expression by antisense treatment prevented the increase in GLO1 and GSR1 mRNA and protein expression.
Title: Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells.
Local overexpression in the mouse brain resulted in increased anxiety-like behaviour; Gsr is involved in oxidative stress metabolism, linking this pathway with anxiety-related behaviour
Title: Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (other) (1) 1 citation
Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI325518 (e-PCR)
- UniSTS:179727

RH125296 (e-PCR)
- UniSTS:162118

NoName (e-PCR)
- UniSTS:225354

RH126625 (e-PCR)
- UniSTS:167555

Gsr (e-PCR), detects polymorphism
- UniSTS:545945

RH47184 (e-PCR)
- UniSTS:29104

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione-disulfide reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione-disulfide reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione-disulfide reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	IC Inferred by Curator more info	PubMed
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutathione reductase, mitochondrial

Names: GR; GRase; glutathione reductase 1

NP_034474.4

EC 1.8.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010344.4 → NP_034474.4 glutathione reductase, mitochondrial precursor

See identical proteins and their annotated locations for NP_034474.4

Status: VALIDATED

Source sequence(s)

BC056357, BQ178602

Consensus CDS

CCDS22235.1

UniProtKB/Swiss-Prot

P47791, Q7TNC2, Q8BN97, Q8C9Z6

UniProtKB/TrEMBL

Q3TWI5

Related

ENSMUSP00000033992.9, ENSMUST00000033992.9

Conserved Domains (3) summary

TIGR01421
Location:42 → 500

gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial

pfam00070
Location:211 → 287

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam02852
Location:390 → 498

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain