Lpar1 lysophosphatidic acid receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpar1provided by MGI
Official Full Name: lysophosphatidic acid receptor 1provided by MGI
Primary source: MGI:MGI:108429
See related: Ensembl:ENSMUSG00000038668 AllianceGenome:MGI:108429
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Edg2; Kdt2; lpA1; vzg-1; Gpcr26
Summary: Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 20.9), colon adult (RPKM 17.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 32.2 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (58435252..58554601, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (58435252..58554027, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice.
Title: Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice.
Lysophosphatidic acid receptor type-1 mediates brain activation in micro-positron emission tomography analysis in a fibromyalgia-like mouse model.
Title: Lysophosphatidic acid receptor type-1 mediates brain activation in micro-positron emission tomography analysis in a fibromyalgia-like mouse model.
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Title: Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction.
Title: LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction.
Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
Title: Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
Title: Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.
Title: Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.
A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses.
Title: A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses.
Expression of lysophosphatidic acid receptor 1 in the adult female mouse pituitary gland.
Title: Expression of lysophosphatidic acid receptor 1 in the adult female mouse pituitary gland.
Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
Title: Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (1)
Targeted (6) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI326300 (e-PCR)
- UniSTS:179012

Edg2 (e-PCR), detects polymorphism
- UniSTS:143239

Edg2 (e-PCR), detects polymorphism
- UniSTS:143240

UniSTS:143241 (e-PCR)
- UniSTS:143241

Edg2 (e-PCR), detects polymorphism
- UniSTS:143241

D2Mit507 (e-PCR), detects polymorphism
- UniSTS:129428

Edg2 (e-PCR), detects polymorphism
- UniSTS:209584

NoName (e-PCR)
- UniSTS:234928

UniSTS:234929 (e-PCR)
- UniSTS:234929

REN76843 (e-PCR)
- UniSTS:401643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables lysophosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophosphatidic acid receptor activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bleb assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calmodulin dependent kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
colocalizes_with endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 1

Names: G-protein coupled receptor 26; LPA receptor 1; endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2; lysophosphatidic acid receptor Edg-2; rec1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290486.2 → NP_001277415.1 lysophosphatidic acid receptor 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL807748

Consensus CDS

CCDS71391.1

UniProtKB/Swiss-Prot

P61793

UniProtKB/TrEMBL

Q544V2

Related

ENSMUSP00000103196.2, ENSMUST00000107570.2

Conserved Domains (1) summary

cd15344
Location:32 → 304

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001421009.1 → NP_001407938.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_001421010.1 → NP_001407939.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_001421011.1 → NP_001407940.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_001421012.1 → NP_001407941.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_001421013.1 → NP_001407942.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_001421014.1 → NP_001407943.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_001421015.1 → NP_001407944.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_001421016.1 → NP_001407945.1 lysophosphatidic acid receptor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2
NM_010336.2 → NP_034466.2 lysophosphatidic acid receptor 1 isoform 1

See identical proteins and their annotated locations for NP_034466.2

Status: VALIDATED

Source sequence(s)

AK030330, AL807748, CJ152526

Consensus CDS

CCDS18212.1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Related

ENSMUSP00000103201.3, ENSMUST00000107575.9

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
NM_172989.2 → NP_766577.1 lysophosphatidic acid receptor 1 isoform 1

See identical proteins and their annotated locations for NP_766577.1

Status: VALIDATED

Source sequence(s)

AL807748, AL929390

Consensus CDS

CCDS18212.1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Related

ENSMUSP00000052581.5, ENSMUST00000055018.11

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

58435252..58554601 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253215.2 → XP_030109075.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011249932.4 → XP_011248234.1 lysophosphatidic acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_011248234.1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036163685.1 → XP_036019578.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011249930.3 → XP_011248232.1 lysophosphatidic acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_011248232.1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011249933.4 → XP_011248235.1 lysophosphatidic acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_011248235.1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036163686.1 → XP_036019579.1 lysophosphatidic acid receptor 1 isoform X1

UniProtKB/Swiss-Prot

A2AMJ2, O88584, P56487, P61793, P70420, Q61130

UniProtKB/TrEMBL

Q544V2

Conserved Domains (1) summary

cd15344
Location:50 → 322

7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors