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    Gng12 guanine nucleotide binding protein (G protein), gamma 12 [ Mus musculus (house mouse) ]

    Gene ID: 14701, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Gng12provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma 12provided by MGI
    Primary source
    MGI:MGI:1336171
    See related
    Ensembl:ENSMUSG00000036402 AllianceGenome:MGI:1336171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3a; 2010305F15Rik
    Summary
    Predicted to enable G-protein beta-subunit binding activity; PDZ domain binding activity; and phosphate ion binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to colocalize with actin filament. Is expressed in cerebral cortex subventricular zone; genitourinary system; and ventricular layer. Orthologous to human GNG12 (G protein subunit gamma 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 26.2), kidney adult (RPKM 24.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 C1; 6 30.68 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (66873381..66998345)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (66896397..67021361)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36610 Neighboring gene RIKEN cDNA 4930597O21 gene Neighboring gene predicted pseudogene 9794 Neighboring gene STARR-positive B cell enhancer mm9_chr6:66879715-66880015 Neighboring gene predicted gene, 36816 Neighboring gene STARR-seq mESC enhancer starr_16162 Neighboring gene STARR-seq mESC enhancer starr_16163 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_16164 Neighboring gene RIKEN cDNA E230016M11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:66987352-66987653 Neighboring gene predicted gene, 53333 Neighboring gene predicted gene, 25260 Neighboring gene growth arrest and DNA-damage-inducible 45 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gng12 is a novel negative regulator of LPS-induced inflammation in the microglial cell line BV-2. Larson KC, et al. Inflamm Res, 2010 Jan. PMID 19568691
    2. Disruption of G-protein γ5 subtype causes embryonic lethality in mice. Moon AM, et al. PLoS One, 2014. PMID 24599258, Free PMC Article
    3. Lineage dynamics of murine pancreatic development at single-cell resolution. Byrnes LE, et al. Nat Commun, 2018 Sep 25. PMID 30254276, Free PMC Article
    4. Chromosomal mapping of five mouse G protein gamma subunits. Downes GB, et al. Genomics, 1999 Apr 1. PMID 10191100
    5. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
    Names
    heterotrimeric guanine nucleotide-binding protein 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177556.1 → NP_001171027.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

      See identical proteins and their annotated locations for NP_001171027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC107650
      Consensus CDS
      CCDS39502.1
      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Related
      ENSMUSP00000109863.2, ENSMUST00000114225.8
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    2. NM_001177557.1 → NP_001171028.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

      See identical proteins and their annotated locations for NP_001171028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC107650, AK005561, BB851888
      Consensus CDS
      CCDS39502.1
      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Related
      ENSMUSP00000109866.2, ENSMUST00000114228.8
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    3. NM_001177558.1 → NP_001171029.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

      See identical proteins and their annotated locations for NP_001171029.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC107650
      Consensus CDS
      CCDS39502.1
      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Related
      ENSMUSP00000109860.2, ENSMUST00000114222.4
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    4. NM_001177559.1 → NP_001171030.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

      See identical proteins and their annotated locations for NP_001171030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC107650
      Consensus CDS
      CCDS39502.1
      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Related
      ENSMUSP00000109865.2, ENSMUST00000114227.8
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    5. NM_001177560.1 → NP_001171031.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

      See identical proteins and their annotated locations for NP_001171031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC107650, AK162342, BB851888
      Consensus CDS
      CCDS39502.1
      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Related
      ENSMUSP00000109864.2, ENSMUST00000114226.8
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    6. NM_025278.5 → NP_079554.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

      See identical proteins and their annotated locations for NP_079554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC107650, AK159872, BB851888
      Consensus CDS
      CCDS39502.1
      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Related
      ENSMUSP00000046557.7, ENSMUST00000043148.13
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      66873381..66998345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165848.1 → XP_036021741.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Related
      ENSMUSP00000109862.2, ENSMUST00000114224.8
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    2. XM_036165846.1 → XP_036021739.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs

    3. XM_036165845.1 → XP_036021738.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/Swiss-Prot
      Q544P3, Q9DAS9
      UniProtKB/TrEMBL
      A0A0N4SVT3
      Conserved Domains (1) summary
      smart00224
      Location:11 → 72
      GGL; G protein gamma subunit-like motifs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAS9.3 GenPept UniProtKB/Swiss-Prot:Q9DAS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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