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    Gng10 guanine nucleotide binding protein (G protein), gamma 10 [ Mus musculus (house mouse) ]

    Gene ID: 14700, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gng10provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma 10provided by MGI
    Primary source
    MGI:MGI:1336169
    See related
    Ensembl:ENSMUSG00000038607 AllianceGenome:MGI:1336169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3m1
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in several structures, including genitourinary system; integumental system; respiratory system; tail; and vertebral axis musculature. Orthologous to human GNG10 (G protein subunit gamma 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 32.2), whole brain E14.5 (RPKM 22.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B3; 4 32.36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59035156..59041899)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59035156..59041899)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene prostaglandin reductase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9587 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene shortage in chiasmata 1 Neighboring gene STARR-positive B cell enhancer ABC_E10236 Neighboring gene STARR-seq mESC enhancer starr_10367 Neighboring gene predicted gene, 35527 Neighboring gene ribosomal protein SA, pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. Ray K, et al. J Biol Chem, 1995 Sep 15. PMID 7665596
    2. Disruption of G-protein γ5 subtype causes embryonic lethality in mice. Moon AM, et al. PLoS One, 2014. PMID 24599258, Free PMC Article
    3. Cloning, characterization, and genomic structure of the mouse Ikbkap gene. Cuajungco MP, et al. DNA Cell Biol, 2001 Sep. PMID 11747609
    4. Chromosomal mapping of five mouse G protein gamma subunits. Downes GB, et al. Genomics, 1999 Apr 1. PMID 10191100
    5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
    Names
    heterotrimeric guanine nucleotide-binding protein 3m1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025277.3 → NP_079553.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

      See identical proteins and their annotated locations for NP_079553.1

      Status: VALIDATED

      Source sequence(s)
      BB434753, BC061090, BY274678
      Consensus CDS
      CCDS18217.1
      UniProtKB/Swiss-Prot
      A2ALW6, Q56A84, Q9CXP8
      Related
      ENSMUSP00000042705.7, ENSMUST00000041160.13
      Conserved Domains (1) summary
      cd00068
      Location:7 → 63
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      59035156..59041899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXP8.1 GenPept UniProtKB/Swiss-Prot:Q9CXP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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