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    Gnao1 guanine nucleotide binding protein, alpha O [ Mus musculus (house mouse) ]

    Gene ID: 14681, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Gnao1provided by MGI
    Official Full Name
    guanine nucleotide binding protein, alpha Oprovided by MGI
    Primary source
    MGI:MGI:95775
    See related
    Ensembl:ENSMUSG00000031748 AllianceGenome:MGI:95775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gnao; Hg1g; alphaO; Galphao
    Summary
    Enables GTP binding activity and GTPase activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; and locomotory behavior. Located in cell body and dendrite. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Used to study developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 40.0), frontal lobe adult (RPKM 39.2) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C5; 8 45.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94537213..94696016)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93810153..93969388)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26843 Neighboring gene predicted gene, 30606 Neighboring gene STARR-seq mESC enhancer starr_22342 Neighboring gene predicted gene, 39224 Neighboring gene RIKEN cDNA 4930488L21 gene Neighboring gene STARR-seq mESC enhancer starr_22343 Neighboring gene STARR-seq mESC enhancer starr_22344 Neighboring gene VISTA enhancer mm1458 Neighboring gene predicted gene, 53411 Neighboring gene autocrine motility factor receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96561142-96561251 Neighboring gene nudix hydrolase 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice with monoallelic GNAO1 loss exhibit reduced inhibitory synaptic input to cerebellar Purkinje cells. Feng H, et al. J Neurophysiol, 2022 Mar 1. PMID 35080448
    2. Microtubules and Gαo-signaling modulate the preferential secretion of young insulin secretory granules in islet β cells via independent pathways. Hu R, et al. PLoS One, 2021. PMID 34292976, Free PMC Article
    3. Mice Expressing Regulators of G protein Signaling-insensitive Gαo Define Roles of μ Opioid Receptor Gαo and Gαi Subunit Coupling in Inhibition of Presynaptic GABA Release. Bouchet CA, et al. Mol Pharmacol, 2021 Sep. PMID 34135098, Free PMC Article
    4. Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone. Larrivee CL, et al. J Pharmacol Exp Ther, 2020 Apr. PMID 31907305
    5. Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice. Cha HL, et al. Mol Brain, 2019 Jun 20. PMID 31221179, Free PMC Article

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Schwann cell-specific G-protein Galphao (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system.
      Title: The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system.
    2. The regulatory role of Gnao1 protein in diabetic encephalopathy in KK-Ay mice and streptozotocin-induced diabetic rats.
      Title: The regulatory role of Gnao1 protein in diabetic encephalopathy in KK-Ay mice and streptozotocin-induced diabetic rats.
    3. Mice with monoallelic GNAO1 loss exhibit reduced inhibitory synaptic input to cerebellar Purkinje cells.
      Title: Mice with monoallelic GNAO1 loss exhibit reduced inhibitory synaptic input to cerebellar Purkinje cells.
    4. Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation.
      Title: Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation.
    5. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca(2+) Homeostasis.
      Title: NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca(2+) Homeostasis.
    6. Mice Expressing Regulators of G protein Signaling-insensitive Galphao Define Roles of mu Opioid Receptor Galphao and Galphai Subunit Coupling in Inhibition of Presynaptic GABA Release.
      Title: Mice Expressing Regulators of G protein Signaling-insensitive Gαo Define Roles of μ Opioid Receptor Gαo and Gαi Subunit Coupling in Inhibition of Presynaptic GABA Release.
    7. Inhibitory signaling in mammalian olfactory transduction potentially mediated by Galphao.
      Title: Inhibitory signaling in mammalian olfactory transduction potentially mediated by Gα(o).
    8. GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.
      Title: GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.
    9. Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone.
      Title: Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone.
    10. Go-mediated signaling pathway regulates maturation of presynaptic parallel fibers from granule cells and climbing fibers during the cerebellar cortical development.
      Title: Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables corticotropin-releasing hormone receptor 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables corticotropin-releasing hormone receptor 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mu-type opioid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mu-type opioid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to organonitrogen compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_negative_effect vesicle docking involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(o) subunit alpha
    Names
    GTP-binding protein alpha-o subunit
    Go alpha
    heterotrimeric guanine nucleotide-binding protein 1g

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113384.2 → NP_001106855.1  guanine nucleotide-binding protein G(o) subunit alpha isoform B

      See identical proteins and their annotated locations for NP_001106855.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) includes alternate exons in the 3' coding region, compared to variant a, resulting in isoform b (also known as G0B-alpha) that has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC102398, AC138118
      Consensus CDS
      CCDS85585.1
      UniProtKB/Swiss-Prot
      P18872
      Related
      ENSMUSP00000148550.2, ENSMUST00000138659.9
      Conserved Domains (2) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:14 → 352
      G_alpha; G protein alpha subunit

    2. NM_001414907.1 → NP_001401836.1  guanine nucleotide-binding protein G(o) subunit alpha isoform A

      Status: VALIDATED

      Source sequence(s)
      AC102398, AC138118
      UniProtKB/Swiss-Prot
      P18872, P18873
      UniProtKB/TrEMBL
      Q543S2
      Related
      ENSMUSP00000114144.2, ENSMUST00000125716.8

    3. NM_001414908.1 → NP_001401837.1  guanine nucleotide-binding protein G(o) subunit alpha isoform C

      Status: VALIDATED

      Source sequence(s)
      AC102398, AC138118

    4. NM_010308.4 → NP_034438.1  guanine nucleotide-binding protein G(o) subunit alpha isoform A

      See identical proteins and their annotated locations for NP_034438.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the shorter transcript and encodes isoform a, also known as G0A-alpha.
      Source sequence(s)
      AC102398, AC138118
      Consensus CDS
      CCDS22532.1
      UniProtKB/Swiss-Prot
      P18872, P18873
      UniProtKB/TrEMBL
      Q543S2
      Related
      ENSMUSP00000034198.9, ENSMUST00000034198.15
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RNA

    1. NR_188943.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102398, AC138118

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94537213..94696016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18872.3 GenPept UniProtKB/Swiss-Prot:P18872

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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