Gna11 guanine nucleotide binding protein, alpha 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gna11provided by MGI
Official Full Name: guanine nucleotide binding protein, alpha 11provided by MGI
Primary source: MGI:MGI:95766
See related: Ensembl:ENSMUSG00000034781 AllianceGenome:MGI:95766
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dsk7; Hg1k; E430025L19; g alpha-11
Summary: Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activity; and alkylglycerophosphoethanolamine phosphodiesterase activity. Involved in several processes, including cranial skeletal system development; endothelin receptor signaling pathway; and multicellular organism aging. Acts upstream of or within several processes, including cellular response to pH; phospholipase C-activating dopamine receptor signaling pathway; and regulation of melanocyte differentiation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in several structures, including adrenal gland; alimentary system; cardiovascular system; central nervous system; and genitourinary system. Used to study autosomal dominant hypocalcemia 2. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 262.5), small intestine adult (RPKM 254.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81364558..81380996, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81528724..81545162, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Galphaq/11 or Galphas Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.
Title: Deletion of Gαq/11 or Gαs Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.
The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.
Title: The orphan receptor GPR139 signals via G(q/11) to oppose opioid effects.
This study demonstrated that balance in the expression of Go1alpha and Go2alpha sustains normal motor function. Deletion of either splice variant results in divergent behavioural and molecular alterations in the striatal dopaminergic system.
Title: Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.
RasGRP3 is specifically required for GNAQ/GNA11-driven Ras activation and tumorigenesis.
Title: GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.
Study has revealed Dsk7 mice harboring a germline hypermorphic Galpha11 mutation, Ile62Val, to have hypocalcemia and reduced PTH concentrations, which are caused by a gain-of-function Gna11 mutation that leads to upregulation of CaSR-mediated Ca2+ and MAPK signaling responses.
Title: Gα(11) mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.
GNA11R60C mutant knockin mice mimic the human autosomal-dominant hypocalcemia type 2 (ADH2) disease, with hypocalcemia and inappropriately low PTH levels demonstrating that this mutation is sufficient to cause ADH2.
Title: Knockin mouse with mutant Gα(11) mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.
Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone and exercise
Title: Overexpression of Gα11 in Osteoblast Lineage Cells Suppresses the Osteoanabolic Response to Intermittent PTH and Exercise.
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
Title: Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
Title: Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation.
In Galpha11-knock-out mice there is a decreased heart rate and increased ejection fraction.
Title: Cardiac remodeling in Gαq and Gα11 knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gna11 (e-PCR), detects polymorphism
- UniSTS:496663

NoName (e-PCR)
- UniSTS:236416

NoName (e-PCR)
- UniSTS:224669

RH127565 (e-PCR)
- UniSTS:210875

Gna11 (e-PCR), detects polymorphism
- UniSTS:257019

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein activity	ISO Inferred from Sequence Orthology more info	PubMed
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables alkylglycerophosphoethanolamine phosphodiesterase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables enzyme regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info	PubMed
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cranial skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISA Inferred from Sequence Alignment more info	PubMed
part_of heterotrimeric G-protein complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of heterotrimeric G-protein complex	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit alpha-11

Names: G-protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1k

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.