Gjb5 gap junction protein, beta 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gjb5provided by MGI
Official Full Name: gap junction protein, beta 5provided by MGI
Primary source: MGI:MGI:95723
See related: Ensembl:ENSMUSG00000042357 AllianceGenome:MGI:95723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cxna; Gjb-5; Cx31.1; Cnx31.1
Summary: Predicted to enable gap junction channel activity. Acts upstream of or within labyrinthine layer morphogenesis; spongiotrophoblast differentiation; and trophoblast giant cell differentiation. Predicted to be located in gap junction and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of connexin complex. Is expressed in early conceptus; reproductive system; sensory organ; and skin. Orthologous to human GJB5 (gap junction protein beta 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 18.0), colon adult (RPKM 3.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 61.51 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (127248600..127251957, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (127354809..127358164, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings show delayed differentiation of connexin31.1 (Gjb5)-deficient trophoblast stem cell.
Title: Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development.
gap-junctions featuring the Cx31.1 protein might be involved in open-field exploration as well as object memory and modulate levels of acetylcholine esterase and cAMP response element-binding protein in the striatum and piriform cortex
Title: Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex.
Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse.
Title: Characterization of connexin31.1-deficient mice reveals impaired placental development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

Gjb5 (e-PCR), detects polymorphism
- UniSTS:527360

Gjb5 (e-PCR), detects polymorphism
- UniSTS:226051

Gjb5 (e-PCR), detects polymorphism
- UniSTS:496776

Gjb5 (e-PCR), detects polymorphism
- UniSTS:502709

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spongiotrophoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gap junction beta-5 protein

Names: connexin a; connexin-31.1; gap junction membrane channel protein beta 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.