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    Gja10 gap junction protein, alpha 10 [ Mus musculus (house mouse) ]

    Gene ID: 14610, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gja10provided by MGI
    Official Full Name
    gap junction protein, alpha 10provided by MGI
    Primary source
    MGI:MGI:1339969
    See related
    Ensembl:ENSMUSG00000051056 AllianceGenome:MGI:1339969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cx59; Cxnn; cx57; Cx-57
    Summary
    Enables gap junction channel activity. Acts upstream of or within detection of light stimulus involved in visual perception; gamete generation; and synapse assembly. Located in gap junction. Is expressed in several structures, including gonad; heart; intestine; lung; and metanephros. Orthologous to human GJA10 (gap junction protein alpha 10). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Gja10 in Genome Data Viewer
    Location:
    4 A5; 4 14.25 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32594595..32607382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32600865..32602382, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4615 Neighboring gene STARR-positive B cell enhancer ABC_E7959 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32345161-32345344 Neighboring gene nuclear encoded tRNA glycine 3 (anticodon CCC) Neighboring gene BTB and CNC homology, basic leucine zipper transcription factor 2 Neighboring gene VISTA enhancer mm720 Neighboring gene STARR-positive B cell enhancer ABC_E7960 Neighboring gene STARR-positive B cell enhancer ABC_E11713 Neighboring gene STARR-positive B cell enhancer ABC_E6157 Neighboring gene STARR-positive B cell enhancer ABC_E1639 Neighboring gene STARR-positive B cell enhancer mm9_chr4:32478184-32478485 Neighboring gene STARR-seq mESC enhancer starr_09864 Neighboring gene VISTA enhancer mm510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32647355-32647538 Neighboring gene STARR-seq mESC enhancer starr_09865 Neighboring gene STARR-positive B cell enhancer ABC_E6158 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene caspase 8 associated protein 2 Neighboring gene midasin AAA ATPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets.
      Title: Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets.
    2. Study showed that mouse horizontal cells establish a coupled dendritic network by Cx57 and two coupled axon terminal networks, one made of Cx50 and the other made of Cx57 channels
      Title: Connexin50 couples axon terminals of mouse horizontal cells by homotypic gap junctions.
    3. Cx57 positive cells are clustered into small groups to form different patterns in the olfactory epithelium; within the sensory epithelial layer, hybridization signal is visible in sublayers containing cell bodies of basal cells and olfactory neurons.
      Title: Expression of connexin 57 in the olfactory epithelium and olfactory bulb.
    4. connexin genes Gjd2 coding for mCx36, Gjc1 coding for mCx45 and Gja10 coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59) and GJA10 (Cx62), could be detected at least as transcript isoforms in the human retina.
      Title: Expression of connexin genes in the human retina.
    5. The study confirmed the expression of Cx57 in the horizontal cells of the retinal outer plexiform layer, the cerebellum and pre-cerebellar.
      Title: Expression of connexin57 in mouse development and in harmaline-tremor model.
    6. the open channel probability of Cx57 gap junctions can be modulated by pH(i) with very high efficiency in the physiologically relevant range and may explain pH-dependent regulation of cell-cell coupling in horizontal cell in the retina
      Title: Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina.
    7. study shows for the first time the detailed location of connexin57 expression within mouse horizontal cells
      Title: Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light.
    8. Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse model.
      Title: Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse model.
    9. These data thus provide the first quantification of mouse horizontal cell receptive field size and confirm the unique role of Cx57 in horizontal cell coupling and physiology.
      Title: Horizontal cell receptive fields are reduced in connexin57-deficient mice.
    10. Cx57 is the first connexin identified in mammalian horizontal cells and the first connexin whose expression is apparently restricted to only one type of neuron.
      Title: Functional expression of connexin57 in horizontal cells of the mouse retina.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gamete generation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gap junction alpha-10 protein
    Names
    connexin n
    connexin-57
    gap junction membrane channel protein alpha 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411853.1 → NP_001398782.1  gap junction alpha-10 protein

      Status: VALIDATED

      Source sequence(s)
      AL831746
      Related
      ENSMUSP00000151323.2, ENSMUST00000219644.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      32594595..32607382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010289.2: Suppressed sequence

      Description
      NM_010289.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUS4.2 GenPept UniProtKB/Swiss-Prot:Q9WUS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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