Arhgdig Rho GDP dissociation inhibitor gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgdigprovided by MGI
Official Full Name: Rho GDP dissociation inhibitor gammaprovided by MGI
Primary source: MGI:MGI:108430
See related: Ensembl:ENSMUSG00000073433 AllianceGenome:MGI:108430
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gdi5; RIP2; Rho-GDI2; Rho-GDI-3
Summary: Enables GDP-dissociation inhibitor activity. Acts upstream of or within blastocyst hatching and regulation of protein localization. Located in membrane. Is expressed in several structures, including central nervous system; epithelium; gonad; trigeminal nerve; and upper jaw molar. Orthologous to human ARHGDIG (Rho GDP dissociation inhibitor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 43.0), CNS E18 (RPKM 36.1) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26418157..26420324, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26199183..26201350, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RhoGDI2 is required for PKB and CREB activation and cdc42 expression in astrocyte migration after kainic acid-mediated excitotoxic lesion in mouse brain.
Title: RhoGDI2 expression in astrocytes after an excitotoxic lesion in the mouse hippocampus.
Our results indicate that the overexpression of Rho-GDIgamma maintains Neural stem cells in the stem cell state preventing migration
Title: Overexpression of Rho-GDP-dissociation inhibitor-γ inhibits migration of neural stem cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables Rho GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GDP-dissociation inhibitor 3

Names: Rho GDP dissociation inhibitor (GDI) gamma; guanosine diphosphate (GDP) dissociation inhibitor 5, Rho associated; rho GDI 3; rho-GDI gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.