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    Gdi2 GDP dissociation inhibitor 2 [ Mus musculus (house mouse) ]

    Gene ID: 14569, updated on 11-Apr-2024

    Summary

    Official Symbol
    Gdi2provided by MGI
    Official Full Name
    GDP dissociation inhibitor 2provided by MGI
    Primary source
    MGI:MGI:99845
    See related
    Ensembl:ENSMUSG00000021218 AllianceGenome:MGI:99845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GDIB; Gdi3; GDI-B
    Summary
    Contributes to GTPase activator activity. Acts upstream of or within small GTPase mediated signal transduction. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 83.7), CNS E11.5 (RPKM 57.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gdi2 in Genome Data Viewer
    Location:
    13 A1; 13 1.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (3588075..3616261)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (3538075..3566261)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810429I04 gene Neighboring gene STARR-seq mESC enhancer starr_33483 Neighboring gene STARR-seq mESC enhancer starr_33484 Neighboring gene STARR-positive B cell enhancer ABC_E3071 Neighboring gene predicted gene, 40654 Neighboring gene STARR-positive B cell enhancer ABC_E1159 Neighboring gene transcription activation suppressor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E9151 Neighboring gene STARR-seq mESC enhancer starr_33488 Neighboring gene general transcription factor II A, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33489 Neighboring gene ankyrin repeat and SOCS box-containing 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Rab GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Rab GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IPI
    Inferred from Physical Interaction
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath HDA PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rab GDP dissociation inhibitor beta
    Names
    GDI beta
    GDI-2
    GDI-3
    RAB GDP dissociation inhibitor beta-2
    guanosine diphosphate (GDP) dissociation inhibitor 2
    guanosine diphosphate (GDP) dissociation inhibitor 3
    guanosine diphosphate dissociation inhibitor 2
    rab GDI beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008112.4NP_032138.3  rab GDP dissociation inhibitor beta

      See identical proteins and their annotated locations for NP_032138.3

      Status: VALIDATED

      Source sequence(s)
      AK083063, AK143681, AK163431, BY072982
      Consensus CDS
      CCDS36581.1
      UniProtKB/Swiss-Prot
      Q541Z9, Q61598, Q8C530, Q9D8M9
      UniProtKB/TrEMBL
      Q3UUX9
      Related
      ENSMUSP00000152454.2, ENSMUST00000223396.2
      Conserved Domains (1) summary
      pfam00996
      Location:1436
      GDI; GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      3588075..3616261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)