Gast gastrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gastprovided by MGI
Official Full Name: gastrinprovided by MGI
Primary source: MGI:MGI:104768
See related: Ensembl:ENSMUSG00000017165 AllianceGenome:MGI:104768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GAS
Summary: This gene encodes the peptide hormone gastrin, which stimulates gastric acid secretion, proliferation, cell migration and angiogenesis, as well as inhibits apoptosis. The encoded preproprotein undergoes proteolytic processing to generate multiple gastrin peptides differing in size. Mice lacking the encoded protein exhibit a decrease in the number of parietal cells, achlorohydria and a decrease in the colonic proliferation. [provided by RefSeq, Nov 2015]
Expression: Restricted expression toward stomach adult (RPKM 365.6) See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.46 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100225233..100227823)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100334407..100336997)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis.
Title: Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis.
Gastrin induces nuclear export and proteasome degradation of menin in duodenal glial cells.
Title: Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.
PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis.
Title: Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells.
Renal-selective silencing of Gast by the renal subcapsular injection of Gast siRNA in BALB/c mice decreases renal dopamine production and increases blood pressure.
Title: Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of l-DOPA.
Gastrin is expressed in insulin secreting cells of adult diabetic mice.
Title: Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.
CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF in gastric epithelial cells.
Title: Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion.
increased circulating concentrations of progastrin provide a physiological advantage against systemic hypoxia in mice
Title: Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions.
Ihh signaling mediates gastrin-induced proliferation of epithelial cells in stomachs of adult mice.
Title: Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.
mouse corneal afferent sensory neurons expressed CCK and GAST, and the CCK1R receptors.
Title: Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea.
Data indicate that epithelial Gli2 expression was sufficient to stimulate Il-1beta expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia.
Title: Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Gast (e-PCR), detects polymorphism
- UniSTS:143168

Gast (e-PCR), detects polymorphism
- UniSTS:143169

Gast (e-PCR), detects polymorphism
- UniSTS:526995

Gast (e-PCR), detects polymorphism
- UniSTS:525487

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to food	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gastrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.