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    Gart phosphoribosylglycinamide formyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 14450, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gartprovided by MGI
    Official Full Name
    phosphoribosylglycinamide formyltransferaseprovided by MGI
    Primary source
    MGI:MGI:95654
    See related
    Ensembl:ENSMUSG00000022962 AllianceGenome:MGI:95654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gaps; Prgs
    Summary
    Enables phosphoribosylamine-glycine ligase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.3), liver E14 (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C3.3; 16 53.18 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91418283..91444505, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91621395..91646972, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 50B Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91588013-91588235 Neighboring gene STARR-positive B cell enhancer ABC_E3173 Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein Neighboring gene downstream neighbor of SON Neighboring gene STARR-positive B cell enhancer ABC_E2468

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase. Sanghani SP, et al. Biochemistry, 1997 Aug 26. PMID 9265631
    2. Analysis of a mouse gene encoding three steps of purine synthesis reveals use of an intronic polyadenylation signal without alternative exon usage. Kan JL, et al. J Biol Chem, 1995 Jan 27. PMID 7829519
    3. Mouse cDNAs encoding a trifunctional protein of de novo purine synthesis and a related single-domain glycinamide ribonucleotide synthetase. Kan JL, et al. Gene, 1993 Dec 31. PMID 8299947
    4. Negative and positive cis-acting elements in the promoter of the mouse gene that encodes the serine/glycine-rich peptide core of secretory granule proteoglycans. Avraham S, et al. J Biol Chem, 1992 Jan 5. PMID 1730621
    5. Comparative gene mapping of human chromosome 21 and mouse chromosome 16. Cox DR, et al. Ann N Y Acad Sci, 1985. PMID 3160288

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylamine-glycine ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables phosphoribosylglycinamide formyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in 'de novo' XMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' XMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in GMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in adenine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to inorganic substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organic substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trifunctional purine biosynthetic protein adenosine-3
    Names
    glycinamide ribonucleotide synthetase
    glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide formyltransferase
    NP_001344280.1
    NP_001412023.1
    NP_001412024.1
    NP_034386.2
    XP_036015674.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357351.2 → NP_001344280.1  trifunctional purine biosynthetic protein adenosine-3

      Status: VALIDATED

      Source sequence(s)
      AC131691
      Consensus CDS
      CCDS28329.1
      UniProtKB/Swiss-Prot
      Q3TGI3, Q64737, Q6NS48
      UniProtKB/TrEMBL
      Q3UJP8
      Related
      ENSMUSP00000156002.2, ENSMUST00000232289.2
      Conserved Domains (3) summary
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4 → 427
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional

    2. NM_001425094.1 → NP_001412023.1  trifunctional purine biosynthetic protein adenosine-3

      Status: VALIDATED

      Source sequence(s)
      AC131691
      UniProtKB/Swiss-Prot
      Q3TGI3, Q64737, Q6NS48

    3. NM_001425095.1 → NP_001412024.1  trifunctional purine biosynthetic protein adenosine-3

      Status: VALIDATED

      Source sequence(s)
      AC131691
      UniProtKB/Swiss-Prot
      Q3TGI3, Q64737, Q6NS48

    4. NM_010256.3 → NP_034386.2  trifunctional purine biosynthetic protein adenosine-3

      See identical proteins and their annotated locations for NP_034386.2

      Status: VALIDATED

      Source sequence(s)
      AC131691
      Consensus CDS
      CCDS28329.1
      UniProtKB/Swiss-Prot
      Q3TGI3, Q64737, Q6NS48
      UniProtKB/TrEMBL
      Q3UJP8
      Related
      ENSMUSP00000023684.8, ENSMUST00000023684.14
      Conserved Domains (3) summary
      cd08645
      Location:809 → 991
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4 → 427
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:435 → 766
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91418283..91444505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159781.1 → XP_036015674.1  trifunctional purine biosynthetic protein adenosine-3 isoform X2

      Conserved Domains (2) summary
      PRK00885
      Location:4 → 427
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:435 → 703
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64737.3 GenPept UniProtKB/Swiss-Prot:Q64737

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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