Gap43 growth associated protein 43 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gap43provided by MGI
Official Full Name: growth associated protein 43provided by MGI
Primary source: MGI:MGI:95639
See related: Ensembl:ENSMUSG00000047261 AllianceGenome:MGI:95639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B-50; Basp2; GAP-43
Summary: Predicted to enable calmodulin binding activity and phospholipid binding activity. Acts upstream of or within axon choice point recognition; cell fate commitment; and glial cell differentiation. Located in several cellular components, including axon; plasma membrane; and postsynaptic density. Is expressed in several structures, including alimentary system; future brain; genitourinary system; nervous system; and sensory organ. Orthologous to human GAP43 (growth associated protein 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 514.6), CNS E14 (RPKM 264.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B4; 16 28.37 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (42068915..42161014, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (42248552..42340651, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth.
Title: JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth.
Mice lacking growth-associated protein 43 develop cardiac remodeling and hypertrophy.
Title: Mice lacking growth-associated protein 43 develop cardiac remodeling and hypertrophy.
Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
Title: Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse.
Title: Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse.
Diabetic mice developed disorganized and debilitated retinal layers with upregulation of the gliosis marker GFAP and downregulation of the neuronal plasticity marker GAP43.
Title: Neuroprotective effect of levetiracetam in mouse diabetic retinopathy: Effect on glucose transporter-1 and GAP43 expression.
Mutation of a predicted N6-methyladenosine (m6A) site in GAP-43 mRNA eliminated its m6A modification and exempted regulation of its local translation by axonal FTO.
Title: Dynamic m6A modification regulates local translation of mRNA in axons.
hnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development.
Title: hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation.
The GASP-43 is involves in the orientation of cell division by interacting with Galphai.
Title: The influence of GAP-43 on orientation of cell division through G proteins.
Trimethyltin decreased synaptophysin but not GAP-43 expression in the mouse hippocampus.
Title: Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning and memory impairment.
Antiretroviral drugs may recruit the HuD-GAP43 pathway, potentially contributing to a response to the antiretroviral neuronal toxicity.
Title: PKC-mediated HuD-GAP43 pathway activation in a mouse model of antiretroviral painful neuropathy.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC337033P3 (e-PCR)
- UniSTS:273167

PMC17794P1 (e-PCR)
- UniSTS:271648

Gap43 (e-PCR), detects polymorphism
- UniSTS:465476

GAP43 (e-PCR)
- UniSTS:479844

WI-18969 (e-PCR)
- UniSTS:26274

UniSTS:265709 (e-PCR)
- UniSTS:265709

Gap43 (e-PCR), detects polymorphism
- UniSTS:265709

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon choice point recognition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon regeneration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within radial glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic specialization assembly	ISO Inferred from Sequence Orthology more info
involved_in tissue regeneration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuromodulin

Names: axonal membrane protein GAP-43; brain abundant, membrane attached signal protein 2; calmodulin-binding protein P-57; growth accentuating protein 43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.