G6pc2 glucose-6-phosphatase, catalytic, 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G6pc2provided by MGI
Official Full Name: glucose-6-phosphatase, catalytic, 2provided by MGI
Primary source: MGI:MGI:1277193
See related: Ensembl:ENSMUSG00000005232 AllianceGenome:MGI:1277193
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IGRP; G6pc-rs
Summary: This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 39.66 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (69041417..69058337)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (69211073..69227993)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.
Title: An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets.
G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity.
Title: G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity.
Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.
Title: Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.
Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic beta-cells.
Title: Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells.
G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting.
Title: G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting.
Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose.
Title: Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose.
These observations suggest that the action of G6PC2 on FBG is largely independent of the influences of environment, modifier genes or epigenetic events, whereas the action of G6PC2 on body weight and cholesterol are influenced by unknown variables.
Title: Effects of G6pc2 deletion on body weight and cholesterol in mice.
G6PC2 may have evolved to modulate FBG in response to stress.
Title: G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.
The observations demonstrate that G6pc2 modulates the complex effects of Dex on both FBG and glucose tolerance.
Title: G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.
Our data clearly indicate that IGRP206-214-specific in vivo CTLs in NOD mice predict diabetes.
Title: Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G6pc-rs (e-PCR), detects polymorphism
- UniSTS:256670

NoName (e-PCR)
- UniSTS:234415

G6pc-rs (e-PCR), detects polymorphism
- UniSTS:186339

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glucose-6-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucose-6-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glucose-6-phosphatase 2

Names: G-6-Pase 2; glucose-6-phosphatase, catalytic, related sequence; islet-specific glucose-6-phosphatase catalytic subunit-related protein

NP_001276785.1

EC 3.1.3.9

NP_001276786.1

EC 3.1.3.9

NP_067306.1

EC 3.1.3.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289856.1 → NP_001276785.1 glucose-6-phosphatase 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK148465, BP758187, BQ557220

UniProtKB/Swiss-Prot

Q9Z186

Conserved Domains (1) summary

cl00474
Location:1 → 162

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
NM_001289857.1 → NP_001276786.1 glucose-6-phosphatase 2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate exon in the coding region resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK148450, BP758187

Consensus CDS

CCDS71066.1

UniProtKB/Swiss-Prot

Q9Z186

Related

ENSMUSP00000107936.3, ENSMUST00000112317.3

Conserved Domains (1) summary

cl00474
Location:38 → 138

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
NM_021331.4 → NP_067306.1 glucose-6-phosphatase 2 isoform 1

See identical proteins and their annotated locations for NP_067306.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK148450, AK148465, BP758187

Consensus CDS

CCDS16089.1

UniProtKB/Swiss-Prot

A2AUN2, Q2M2M7, Q9Z186

Related

ENSMUSP00000005364.6, ENSMUST00000005364.12

Conserved Domains (2) summary

COG0671
Location:36 → 193

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03381
Location:38 → 278

PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...