Fzd7 frizzled class receptor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fzd7provided by MGI
Official Full Name: frizzled class receptor 7provided by MGI
Primary source: MGI:MGI:108570
See related: Ensembl:ENSMUSG00000041075 AllianceGenome:MGI:108570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fz7
Summary: Enables Wnt-activated receptor activity and Wnt-protein binding activity. Involved in negative regulation of cell-substrate adhesion. Acts upstream of or within several processes, including Wnt signaling pathway; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; and substrate adhesion-dependent cell spreading. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 30.08 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (59521306..59526114)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (59482147..59486955)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bioinformatics analysis and experimental validation reveal the anti-ferroptosis effect of FZD7 in acute kidney injury.
Title: Bioinformatics analysis and experimental validation reveal the anti-ferroptosis effect of FZD7 in acute kidney injury.
Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine.
Title: Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine.
A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models.
Title: A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models.
Heat-stable enterotoxin inhibits intestinal stem cell expansion to disrupt the intestinal integrity by downregulating the Wnt/beta-catenin pathway.
Title: Heat-stable enterotoxin inhibits intestinal stem cell expansion to disrupt the intestinal integrity by downregulating the Wnt/β-catenin pathway.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Title: WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
these findings indicated that up-regulated miR-488 may reduce the proliferation, migration and invasion of endometrial glandular epithelial cells through inhibiting the activation of Wnt pathway by down-regulating FZD7.
Title: MicroRNA-488 inhibits endometrial glandular epithelial cell proliferation, migration, and invasion in endometriosis mice via Wnt by inhibiting FZD7.
Molecular analysis revealed that Fzd7 may act through the activation of Wnt/beta-catenin and Jagged1 expression to control EC proliferation in extra-retinal neovessels.
Title: Therapies targeting Frizzled-7/β-catenin pathway prevent the development of pathological angiogenesis in an ischemic retinopathy model.
Wnt7b and Fz7 induce the phosphorylation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and JNK proteins, which are required for dendritic development.
Title: Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK.
a critical role for Wnt-Fz7 signaling in LTP-mediated synaptic accumulation of AMPARs and spine plasticity.
Title: Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors.
these data provide functional evidence of a crucial role for Wnt signalling, via the Fzd7 receptor, during homeostasis of the gastric epithelium.
Title: Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fzd7 (e-PCR), detects polymorphism
- UniSTS:506913

Fzd7 (e-PCR), detects polymorphism
- UniSTS:498742

PMC316619P2 (e-PCR)
- UniSTS:273019

Fzd7 (e-PCR), detects polymorphism
- UniSTS:516480

NoName (e-PCR)
- UniSTS:548584

Fzd7 (e-PCR), detects polymorphism
- UniSTS:508392

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ectodermal cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: frizzled-7

Names: frizzled homolog 7; fz-7; mFz7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008057.3 → NP_032083.3 frizzled-7 precursor

See identical proteins and their annotated locations for NP_032083.3

Status: VALIDATED

Source sequence(s)

AK010239, BC049781, BY233527

Consensus CDS

CCDS14985.1

UniProtKB/Swiss-Prot

G3X953, Q61090

UniProtKB/TrEMBL

Q6P551

Related

ENSMUSP00000109884.3, ENSMUST00000114246.4

Conserved Domains (2) summary

cd07466
Location:45 → 169

CRD_FZ7; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 7 (Fz7) receptor

cd15246
Location:241 → 571

7tmF_FZD7; class F frizzled subfamily 7, member of 7-transmembrane G protein-coupled receptors