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    Dtx1 deltex 1, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 14357, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dtx1provided by MGI
    Official Full Name
    deltex 1, E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:1352744
    See related
    Ensembl:ENSMUSG00000029603 AllianceGenome:MGI:1352744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fxit1; mKIAA4160
    Summary
    Predicted to enable Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including Notch signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 82.7), CNS E18 (RPKM 30.0) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 60.64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120818268..120850879, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120680203..120711867, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 54 Neighboring gene cilia and flagella associated protein 73 Neighboring gene STARR-positive B cell enhancer ABC_E4782 Neighboring gene RAS protein activator like 1 (GAP1 like) Neighboring gene STARR-positive B cell enhancer ABC_E11300 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121135771-121135981 Neighboring gene STARR-positive B cell enhancer ABC_E8075 Neighboring gene STARR-positive B cell enhancer ABC_E6371 Neighboring gene STARR-seq mESC enhancer starr_14247 Neighboring gene STARR-seq mESC enhancer starr_14249 Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene 2'-5' oligoadenylate synthetase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225553-121225736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225792-121225979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic analysis and localization of murine Deltex, a modulator of notch activity, to mouse chromosome 5 and its human homolog to chromosome 12. Pampeno CL, et al. DNA Cell Biol, 2001 Mar. PMID 11313017
    2. A novel cDNA transcript expressed in fractionated X-irradiation-induced murine thymomas. Pampeno CL, et al. Cell Growth Differ, 1996 Aug. PMID 8853908
    3. miR-210-3p Impairs Pancreatic β-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus. Cao X, et al. J Environ Pathol Toxicol Oncol, 2022. PMID 36374959
    4. Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter. Jang J, et al. Cell Death Differ, 2006 Sep. PMID 16341126
    5. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Hsiao HW, et al. Nat Commun, 2015 Feb 19. PMID 25695215, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-210-3p Impairs Pancreatic beta-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus.
      Title: miR-210-3p Impairs Pancreatic β-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus.
    2. exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 protein
      Title: Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
    3. DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
      Title: Deltex1 promotes protein kinase Cθ degradation and sustains Casitas B-lineage lymphoma expression.
    4. Data show that Deltex1 ablation enabled Id1-expressing progenitors to differentiate to the DN3 (CD44(-) CD25(+)) stage, which was accompanied by enhanced Notch1 expression in T-cell progenitors.
      Title: Id1 attenuates Notch signaling and impairs T-cell commitment by elevating Deltex1 expression.
    5. deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
      Title: Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy.
    6. Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development[Deltex1]
      Title: T cells develop normally in the absence of both Deltex1 and Deltex2.
    7. Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1.
      Title: Deltex regulates T-cell activation by targeted degradation of active MEKK1.
    8. NB-3/Notch1 pathway promotes neural progenitor cell differentiation into
      Title: NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.
    9. Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
      Title: Normal immune system development in mice lacking the Deltex-1 RING finger domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4160

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DTX1
    Names
    FXI-T1
    RING-type E3 ubiquitin transferase DTX1
    deltex 1 homolog
    deltex1
    fractionated x-irradiation induced transcript 1
    mDTX1
    protein deltex-1
    NP_001404401.1
    NP_001404402.1
    NP_001404403.1
    NP_032078.2
    XP_011246483.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417472.1 → NP_001404401.1  E3 ubiquitin-protein ligase DTX1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC115937, AC125183

    2. NM_001417473.1 → NP_001404402.1  E3 ubiquitin-protein ligase DTX1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC115937, AC125183
      UniProtKB/Swiss-Prot
      Q3TER5, Q61010, Q8C2H2, Q9ER09

    3. NM_001417474.1 → NP_001404403.1  E3 ubiquitin-protein ligase DTX1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC125183
      UniProtKB/Swiss-Prot
      Q3TER5, Q61010, Q8C2H2, Q9ER09

    4. NM_008052.4 → NP_032078.2  E3 ubiquitin-protein ligase DTX1 isoform b

      See identical proteins and their annotated locations for NP_032078.2

      Status: VALIDATED

      Source sequence(s)
      AC115937, AC125183
      Consensus CDS
      CCDS19624.1
      UniProtKB/Swiss-Prot
      Q3TER5, Q61010, Q8C2H2, Q9ER09
      UniProtKB/TrEMBL
      Q5DTK6
      Related
      ENSMUSP00000031607.7, ENSMUST00000031607.7
      Conserved Domains (3) summary
      smart00678
      Location:26 → 102
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16671
      Location:415 → 483
      RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
      pfam18102
      Location:486 → 620
      DTC; Deltex C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120818268..120850879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248181.4 → XP_011246483.1  E3 ubiquitin-protein ligase DTX1 isoform X1

      See identical proteins and their annotated locations for XP_011246483.1

      UniProtKB/TrEMBL
      Q5DTK6
      Conserved Domains (3) summary
      smart00678
      Location:26 → 102
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd16671
      Location:415 → 487
      RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
      pfam18102
      Location:490 → 624
      DTC; Deltex C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61010.2 GenPept UniProtKB/Swiss-Prot:Q61010

    Gene LinkOut

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