Brd2 bromodomain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brd2provided by MGI
Official Full Name: bromodomain containing 2provided by MGI
Primary source: MGI:MGI:99495
See related: Ensembl:ENSMUSG00000024335 AllianceGenome:MGI:99495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nat; Rnf3; Frg-1; Fsrg1; Ring3; Fsrg-1; mKIAA4005; D17H6S113E
Summary: Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Involved in regulation of gene expression. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; future brain; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 36.3), adrenal adult (RPKM 32.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34330993..34341581, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34112019..34122814, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.
Title: Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.
Ex vivo and cell-based assays revealed that Hdac11 catalytic activity suppresses the BAT transcriptional program, in both the basal state and in response to beta-adrenergic receptor signaling, through a mechanism that is dependent on physical association with Brd2. These findings define an epigenetic pathway for the regulation of energy homeostasis.
Title: HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.
Brd2 triggers insulin resistance via lipolysis-mediated free fatty acids release.
Title: Bromodomain-containing protein 2 promotes lipolysis via ERK/HSL signalling pathway in white adipose tissue of mice.
these results provided evidence for a novel role of Brd2 in chronic inflammation and insulin resistance.
Title: Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissue.
BRD2 acts to augment the boundary function of CTCF both by limiting the spread or range of enhancer activity and by physically preventing the formation of cross-boundary contacts genome-wide.
Title: The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.
Brd2 and Brd4 genetic transcription required for Th17 cell development and adaptive immunity.
Title: Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
This study reveals an antagonistic relationship between H2A.Z.1ub and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs.
Title: H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs.
BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein
Title: The Epigenetic Reader BRD2 as a Specific Modulator of PAI-1 Expression in Lipopolysaccharide-Stimulated Mouse Primary Astrocytes.
DNA demethylation of the Brd2 promoter region induced Brd2 expression during differentiation of 3T3-L1 cells into adipocytes.
Title: DNA methylation regulates bromodomain-containing protein 2 expression during adipocyte differentiation.
Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.
Title: Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Gene trapped (2) 1 citation
Targeted (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CGCb741 (e-PCR)
- UniSTS:240935

CGCbi2 (e-PCR)
- UniSTS:240939

AW228947 (e-PCR)
- UniSTS:186097

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylation-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables acetylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain-containing protein 2

Names: female sterile homeotic-related gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204973.1 → NP_001191902.1 bromodomain-containing protein 2

See identical proteins and their annotated locations for NP_001191902.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK168525, BY244178, CB527269, CO040867

Consensus CDS

CCDS28641.1

UniProtKB/Swiss-Prot

O54795, O88411, Q3UGI0, Q5DTS6, Q794H7, Q794H9, Q7JJ13, Q99PC5

UniProtKB/TrEMBL

B2RS09

Related

ENSMUSP00000025193.7, ENSMUST00000025193.14

Conserved Domains (4) summary

cd05497
Location:73 → 179

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:348 → 449

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:215 → 332

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:639 → 701

BET; Bromodomain extra-terminal - transcription regulation
NM_001424771.1 → NP_001411700.1 bromodomain-containing protein 2

Status: VALIDATED

Source sequence(s)

CR974462

UniProtKB/Swiss-Prot

O54795, O88411, Q3UGI0, Q5DTS6, Q794H7, Q794H9, Q7JJ13, Q99PC5

UniProtKB/TrEMBL

B2RS09
NM_001424772.1 → NP_001411701.1 bromodomain-containing protein 2

Status: VALIDATED

Source sequence(s)

CR974462

UniProtKB/Swiss-Prot

O54795, O88411, Q3UGI0, Q5DTS6, Q794H7, Q794H9, Q7JJ13, Q99PC5

UniProtKB/TrEMBL

B2RS09
NM_010238.3 → NP_034368.2 bromodomain-containing protein 2

See identical proteins and their annotated locations for NP_034368.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the same protein as variant 2.

Source sequence(s)

AK158970, CB246848, CO040867

Consensus CDS

CCDS28641.1

UniProtKB/Swiss-Prot

O54795, O88411, Q3UGI0, Q5DTS6, Q794H7, Q794H9, Q7JJ13, Q99PC5

UniProtKB/TrEMBL

B2RS09

Related

ENSMUSP00000109880.3, ENSMUST00000114242.9

Conserved Domains (4) summary

cd05497
Location:73 → 179

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:348 → 449

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:215 → 332

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:639 → 701

BET; Bromodomain extra-terminal - transcription regulation

RNA

NR_037970.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK147918, BC046809, BM947875

Related

ENSMUST00000154232.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34330993..34341581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160322.1 → XP_036016215.1 bromodomain-containing protein 2 isoform X3

Conserved Domains (4) summary

cd05498
Location:229 → 330

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:96 → 213

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:520 → 582

BET; Bromodomain extra-terminal - transcription regulation

cl02556
Location:1 → 60

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030249501.1 → XP_030105361.1 bromodomain-containing protein 2 isoform X3

Conserved Domains (4) summary

cd05498
Location:229 → 330

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:96 → 213

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:520 → 582

BET; Bromodomain extra-terminal - transcription regulation

cl02556
Location:1 → 60

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_017317255.3 → XP_017172744.1 bromodomain-containing protein 2 isoform X4

Conserved Domains (2) summary

pfam17035
Location:314 → 376

BET; Bromodomain extra-terminal - transcription regulation

cl02556
Location:74 → 124

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_036160323.1 → XP_036016216.1 bromodomain-containing protein 2 isoform X4

Conserved Domains (2) summary

pfam17035
Location:314 → 376

BET; Bromodomain extra-terminal - transcription regulation

cl02556
Location:74 → 124

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030249500.2 → XP_030105360.1 bromodomain-containing protein 2 isoform X2

Related

ENSMUSP00000092990.8, ENSMUST00000095347.13

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:302 → 403

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:169 → 286

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:593 → 655

BET; Bromodomain extra-terminal - transcription regulation

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025387.2: Suppressed sequence

Description

NM_001025387.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.