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    Asb14 ankyrin repeat and SOCS box-containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 142687, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Asb14provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 14provided by MGI
    Primary source
    MGI:MGI:2655107
    See related
    Ensembl:ENSMUSG00000021898 AllianceGenome:MGI:2655107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-14
    Summary
    Predicted to be involved in intracellular signal transduction. Orthologous to human ASB14 (ankyrin repeat and SOCS box containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 27.4) and mammary gland adult (RPKM 3.1) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A3; 14 16.09 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26616547..26638393)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26894590..26915257)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:27489365-27489548 Neighboring gene phosphodiesterase 12 Neighboring gene microRNA 7672 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene predicted gene, 34415 Neighboring gene STARR-seq mESC enhancer starr_36242 Neighboring gene STARR-seq mESC enhancer starr_36244 Neighboring gene predicted gene, 41115 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Neighboring gene predicted gene, 41114

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
    2. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 14
    Names
    ankyrin repeat and SOCS box-containing protein 14
    ankyrin repeat domain-containing SOCS box protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170748.2 → NP_001164219.2  ankyrin repeat and SOCS box protein 14 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK052884, BC145002
      Consensus CDS
      CCDS49431.2
      UniProtKB/Swiss-Prot
      B7ZN45, Q8C6Y6, Q8VHS7
      UniProtKB/TrEMBL
      A0A5F8MPW7
      Related
      ENSMUSP00000159151.2, ENSMUST00000238987.2
      Conserved Domains (4) summary
      PHA02875
      Location:116 → 343
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:182 → 213
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:319 → 413
      Ank_2; Ankyrin repeats (3 copies)
      cl02533
      Location:529 → 585
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    2. NM_080856.5 → NP_543132.4  ankyrin repeat and SOCS box protein 14 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK052884
      Consensus CDS
      CCDS36842.3
      UniProtKB/TrEMBL
      A0A0R4J236, A0A5F8MPK4
      Related
      ENSMUSP00000159012.2, ENSMUST00000239004.2
      Conserved Domains (3) summary
      PHA02875
      Location:116 → 343
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:182 → 213
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:319 → 413
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      26616547..26638393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518555.5 → XP_006518618.1  ankyrin repeat and SOCS box protein 14 isoform X1

      UniProtKB/TrEMBL
      E9QPD0
      Conserved Domains (4) summary
      PHA02875
      Location:145 → 372
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:211 → 242
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:348 → 442
      Ank_2; Ankyrin repeats (3 copies)
      cl02533
      Location:558 → 614
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    2. XM_011244955.3 → XP_011243257.1  ankyrin repeat and SOCS box protein 14 isoform X2

      See identical proteins and their annotated locations for XP_011243257.1

      UniProtKB/Swiss-Prot
      B7ZN45, Q8C6Y6, Q8VHS7
      Conserved Domains (4) summary
      PHA02875
      Location:15 → 242
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:81 → 112
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:218 → 312
      Ank_2; Ankyrin repeats (3 copies)
      cl02533
      Location:428 → 484
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    3. XM_036158465.1 → XP_036014358.1  ankyrin repeat and SOCS box protein 14 isoform X3

      Conserved Domains (3) summary
      sd00045
      Location:18 → 49
      ANK; ANK repeat [structural motif]
      cl02533
      Location:365 → 421
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl39094
      Location:5 → 253
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C6Y6.2 GenPept UniProtKB/Swiss-Prot:Q8C6Y6

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