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    Flt3l FMS-like tyrosine kinase 3 ligand [ Mus musculus (house mouse) ]

    Gene ID: 14256, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Flt3lprovided by MGI
    Official Full Name
    FMS-like tyrosine kinase 3 ligandprovided by MGI
    Primary source
    MGI:MGI:95560
    See related
    Ensembl:ENSMUSG00000110206 AllianceGenome:MGI:95560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly72L; Flt3lg
    Summary
    Enables identical protein binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including positive regulation of cell population proliferation; positive regulation of nitrogen compound metabolic process; and regulation of leukocyte activation. Located in cell surface and extracellular space. Is intrinsic component of external side of plasma membrane. Is expressed in several structures, including central nervous system; liver; retina; spleen; and yolk sac. Human ortholog(s) of this gene implicated in colon carcinoma; glioblastoma; and high grade glioma. Orthologous to human FLT3LG (fms related receptor tyrosine kinase 3 ligand). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 26.3), lung adult (RPKM 25.1) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.14 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44780607..44785914, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45131183..45136490, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13A Neighboring gene small nucleolar RNA, C/D box 32A Neighboring gene small nucleolar RNA, C/D box 33 Neighboring gene microRNA 5121 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52391576-52391763 Neighboring gene aldehyde dehydrogenase 16 family, member A1 Neighboring gene STARR-seq mESC enhancer starr_18831 Neighboring gene PIH1 domain containing 1 Neighboring gene solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 Neighboring gene microRNA 7055

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Sikder MAA, et al. Immunity, 2023 May 9. PMID 37003256
    2. Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction. Thummar K, et al. Sci Rep, 2022 Jul 19. PMID 35853935, Free PMC Article
    3. FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation. Audiger C, et al. J Immunol, 2020 Oct 15. PMID 32887750
    4. Fms-Like Tyrosine Kinase-3 Ligand Attenuates Local and Systemic Infection in a Model of Post-Burn Pneumonia. Hundeshagen G, et al. Shock, 2018 Jun. PMID 28796661
    5. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150(+) long-term repopulating murine hematopoietic stem cells. Tornack J, et al. Eur J Immunol, 2017 Sep. PMID 28667750

    See all (189) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors.
      Title: FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors.
    2. Identification of dendritic cell precursor from the CD11c[+] cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand.
      Title: Identification of dendritic cell precursor from the CD11c(+) cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand.
    3. Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection.
      Title: Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection.
    4. Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction.
      Title: Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction.
    5. FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation.
      Title: FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation.
    6. Study demonstrated that conventional dendritic cells 2 (cDC2s) produced their own FLT3L and utilized the transmembrane metalloproteinase ADAM10 to shed membrane bound FLT3L into soluble forms. This process was crucial for cDC2s to develop and survive in the spleen. These findings likely represent cell-autonomous developmental and survival processes that enable cDC2s to preferentially gain access to FLT3L.
      Title: Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.
    7. Data indicate that combined over-expression of interleukin 7 (IL-7) and FMS-like tyrosine kinase 3 ligand (FL) leads to a massive expansion of most bone marrow hematopoietic progenitors.
      Title: Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand.
    8. Fms-Like Tyrosine Kinase-3 Ligand Attenuates Local and Systemic Infection in a Model of Post-Burn Pneumonia.
      Title: Fms-Like Tyrosine Kinase-3 Ligand Attenuates Local and Systemic Infection in a Model of Post-Burn Pneumonia.
    9. the discrepancy between Flt3(-/-) and Flt3l(-/-) mice results from the increased sensitivity of Flt3(-/-) progenitors to these cytokines.
      Title: Altered compensatory cytokine signaling underlies the discrepancy between Flt3(-/-) and Flt3l(-/-) mice.
    10. These observations emphasize the potential of Flt3L as an adjuvant for colon cancer DNA vaccines.
      Title: Enhancement of anti-tumor effect of plasmid DNA-carrying MUC1 by the adjuvanticity of FLT3L in mouse model.
    Submit: New GeneRIF Correction See all GeneRIFs (77)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process in bone marrow cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of osteoclast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of osteoclast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of myeloid dendritic cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fms-related tyrosine kinase 3 ligand
    Names
    flt3 ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402831.1 → NP_001389760.1  fms-related tyrosine kinase 3 ligand isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256

    2. NM_001402832.1 → NP_001389761.1  fms-related tyrosine kinase 3 ligand isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/Swiss-Prot
      P49772, Q64085
      UniProtKB/TrEMBL
      A9QW46

    3. NM_001402833.1 → NP_001389762.1  fms-related tyrosine kinase 3 ligand isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/Swiss-Prot
      P49772, Q64085
      UniProtKB/TrEMBL
      A9QW46
      Related
      ENSMUSP00000147468.2, ENSMUST00000211429.2

    4. NM_001402834.1 → NP_001389763.1  fms-related tyrosine kinase 3 ligand isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/Swiss-Prot
      P49772, Q64085
      UniProtKB/TrEMBL
      A9QW46

    5. NM_001402835.1 → NP_001389764.1  fms-related tyrosine kinase 3 ligand isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256

    6. NM_001402836.1 → NP_001389765.1  fms-related tyrosine kinase 3 ligand isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256

    7. NM_001402837.1 → NP_001389766.1  fms-related tyrosine kinase 3 ligand isoform d

      Status: VALIDATED

      Source sequence(s)
      AC126256

    8. NM_013520.4 → NP_038548.3  fms-related tyrosine kinase 3 ligand isoform b precursor

      See identical proteins and their annotated locations for NP_038548.3

      Status: VALIDATED

      Source sequence(s)
      AC126256
      Consensus CDS
      CCDS39948.1
      UniProtKB/Swiss-Prot
      P49772, Q64085
      UniProtKB/TrEMBL
      A0A1B0GRC9, A9QW46
      Related
      ENSMUSP00000123506.2, ENSMUST00000146760.7
      Conserved Domains (1) summary
      pfam02947
      Location:30 → 162
      Flt3_lig; flt3 ligand

    RNA

    1. NR_102725.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256
      Related
      ENSMUST00000210818.2

    2. NR_175301.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    3. NR_175302.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    4. NR_175303.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    5. NR_175304.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    6. NR_175305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    7. NR_175306.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    8. NR_175307.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44780607..44785914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152676.1 → XP_036008569.1  fms-related tyrosine kinase 3 ligand isoform X3

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Conserved Domains (1) summary
      pfam02947
      Location:62 → 190
      Flt3_lig; flt3 ligand

    2. XM_036152675.1 → XP_036008568.1  fms-related tyrosine kinase 3 ligand isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Related
      ENSMUSP00000148009.2, ENSMUST00000210197.2
      Conserved Domains (1) summary
      pfam02947
      Location:62 → 190
      Flt3_lig; flt3 ligand

    3. XM_036152674.1 → XP_036008567.1  fms-related tyrosine kinase 3 ligand isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Conserved Domains (1) summary
      pfam02947
      Location:62 → 190
      Flt3_lig; flt3 ligand

    4. XM_006540612.4 → XP_006540675.1  fms-related tyrosine kinase 3 ligand isoform X6

      See identical proteins and their annotated locations for XP_006540675.1

      UniProtKB/TrEMBL
      A0A1B0GRC9
      Conserved Domains (1) summary
      pfam02947
      Location:62 → 194
      Flt3_lig; flt3 ligand

    5. XM_036152677.1 → XP_036008570.1  fms-related tyrosine kinase 3 ligand isoform X4

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Conserved Domains (1) summary
      pfam02947
      Location:53 → 181
      Flt3_lig; flt3 ligand

    6. XM_036152673.1 → XP_036008566.1  fms-related tyrosine kinase 3 ligand isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Conserved Domains (1) summary
      pfam02947
      Location:53 → 181
      Flt3_lig; flt3 ligand

    7. XM_036152671.1 → XP_036008564.1  fms-related tyrosine kinase 3 ligand isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Conserved Domains (1) summary
      pfam02947
      Location:53 → 181
      Flt3_lig; flt3 ligand

    8. XM_036152672.1 → XP_036008565.1  fms-related tyrosine kinase 3 ligand isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Conserved Domains (1) summary
      pfam02947
      Location:53 → 181
      Flt3_lig; flt3 ligand

    9. XM_036152670.1 → XP_036008563.1  fms-related tyrosine kinase 3 ligand isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSN6
      Conserved Domains (1) summary
      pfam02947
      Location:53 → 181
      Flt3_lig; flt3 ligand

    RNA

    1. XR_882018.2 RNA Sequence

    2. XR_004934016.1 RNA Sequence

    3. XR_882016.2 RNA Sequence

    4. XR_004934014.1 RNA Sequence

    5. XR_882017.3 RNA Sequence

    6. XR_004934015.1 RNA Sequence

    7. XR_882012.3 RNA Sequence

    8. XR_882010.3 RNA Sequence

    9. XR_004934013.1 RNA Sequence

    10. XR_004934012.1 RNA Sequence

    11. XR_004934011.1 RNA Sequence

    12. XR_004934010.1 RNA Sequence

    13. XR_004934009.1 RNA Sequence

    14. XR_004934008.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49772.1 GenPept UniProtKB/Swiss-Prot:P49772

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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