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    Fli1 Friend leukemia integration 1 [ Mus musculus (house mouse) ]

    Gene ID: 14247, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fli1provided by MGI
    Official Full Name
    Friend leukemia integration 1provided by MGI
    Primary source
    MGI:MGI:95554
    See related
    Ensembl:ENSMUSG00000016087 AllianceGenome:MGI:95554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sic1; EWSR2; Fli-1; SIC-1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; genitourinary system; and nervous system. Used to study systemic scleroderma. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 10.2), thymus adult (RPKM 7.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A4; 9 17.74 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32333500..32454292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32422204..32543432, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:32157923-32158223 Neighboring gene STARR-positive B cell enhancer ABC_E38 Neighboring gene STARR-seq mESC enhancer starr_23730 Neighboring gene predicted gene, 39317 Neighboring gene STARR-seq mESC enhancer starr_23731 Neighboring gene predicted gene, 31755 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene predicted gene, 22060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32303340-32303523 Neighboring gene STARR-seq mESC enhancer starr_23734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32313794-32313977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32317387-32317633 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32323433-32323734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32325957-32326225 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32345741-32346052 Neighboring gene STARR-positive B cell enhancer ABC_E6720 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32397521-32397822 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32399361-32399662 Neighboring gene STARR-positive B cell enhancer ABC_E2885 Neighboring gene predicted gene, 31871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32423579-32423876 Neighboring gene predicted gene, 31928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease. Li P, et al. Mol Ther, 2022 Apr 6. PMID 35038582, Free PMC Article
    2. In vivo CD8(+) T cell CRISPR screening reveals control by Fli1 in infection and cancer. Chen Z, et al. Cell, 2021 Mar 4. PMID 33636129, Free PMC Article
    3. Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells. Saigusa R, et al. Arthritis Res Ther, 2018 Feb 7. PMID 29415756, Free PMC Article
    4. Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis. Yamashita T, et al. J Invest Dermatol, 2017 Mar. PMID 27777101, Free PMC Article
    5. FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain. Sundararaj KP, et al. J Immunol, 2015 Dec 15. PMID 26538397, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis.
      Title: Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis.
    2. Transcription factor Fli-1 impacts the expression of CXCL13 and regulates immune cell infiltration into the kidney in MRL/lpr mouse.
      Title: Transcription factor Fli-1 impacts the expression of CXCL13 and regulates immune cell infiltration into the kidney in MRL/lpr mouse.
    3. Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease.
      Title: Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease.
    4. Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors.
      Title: Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors.
    5. Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis.
      Title: Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis.
    6. In vivo CD8(+) T cell CRISPR screening reveals control by Fli1 in infection and cancer.
      Title: In vivo CD8(+) T cell CRISPR screening reveals control by Fli1 in infection and cancer.
    7. Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
      Title: Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
    8. These results indicate that Fli1 loss promotes CXCL13 expression in macrophages even though stimulated with LPS, a potent inhibitory factor for CXCL13 expression.
      Title: CXCL13 produced by macrophages due to Fli1 deficiency may contribute to the development of tissue fibrosis, vasculopathy and immune activation in systemic sclerosis.
    9. Data suggest a critical role of Friend leukemia integration 1 protein (Fli1) deficiency in the interaction of dermal fibroblasts with immune cells in pathological skin fibrosis.
      Title: Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells.
    10. findings demonstrated a novel role and mechanism of Fli-1 in regulating caspase-1 expression in lung pericytes.
      Title: Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes.
    Submit: New GeneRIF Correction See all GeneRIFs (62)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (11)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Friend leukemia integration 1 transcription factor
    Names
    retroviral integration site protein Fli-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410251.1 → NP_001397180.1  Friend leukemia integration 1 transcription factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127581, AC141646

    2. NM_001410252.1 → NP_001397181.1  Friend leukemia integration 1 transcription factor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127581, AC141646

    3. NM_008026.6 → NP_032052.1  Friend leukemia integration 1 transcription factor isoform 1

      See identical proteins and their annotated locations for NP_032052.1

      Status: VALIDATED

      Source sequence(s)
      AC127581, AC141646
      Consensus CDS
      CCDS40571.1
      UniProtKB/Swiss-Prot
      P26323
      UniProtKB/TrEMBL
      Q544B3, Q8BZ56
      Related
      ENSMUSP00000016231.7, ENSMUST00000016231.14
      Conserved Domains (2) summary
      cd08541
      Location:114 → 204
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:280 → 363
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      32333500..32454292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510009.4 → XP_006510072.1  Friend leukemia integration 1 transcription factor isoform X2

      See identical proteins and their annotated locations for XP_006510072.1

      UniProtKB/TrEMBL
      Q8BZ56
      Conserved Domains (2) summary
      cd08541
      Location:81 → 171
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:247 → 330
      ETS; erythroblast transformation specific domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26323.1 GenPept UniProtKB/Swiss-Prot:P26323

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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